BACKGROUND Multiple procedures have been advocated for the surgical control of chronic sialorrhea in children. However, some of them are associated with significant complications or only short-term success. OBJECTIVES To evaluate the safety of bilateral submandibular gland excision (SGE) with parotid duct ligation (PDL) and to assess its long-term complications and efficacy in the treatment o...

Sialorrhea affects a significant number of children with cerebral palsy and other neuromuscular disorders. It can lead not only to social embarrassment but also to severe medical issues including chronic aspiration. There are numerous medical and surgical options, which include oral medications and transdermal patches, botulinum injection, and various forms of surgical ligation or excision of t...

Introduction Clozapine is a second-generation antipsychotic, which use is limited to treatment-resistant cases of schizophrenia. Sialorrhea, a well-known side effect of clozapine, occurs in 31–54% of patients receiving clozapine therapy (1). Patients may complain of both daytime and nighttime drooling (the “wet pillow” sign). Here, we report the case of a young man who developed aspiration pneu...

Background/Aim. Botulinum toxin-A (BTX-A) is known to block the release of acetylcholine from motor and autonomic nerve terminals and may significantly decrease saliva production when injected intraglandulary. The aim of this study was to evaluate effects of BTX-A injections in the treatment of disabling sialorrhea in various neurological disorders. Methods. This study included 19 consecutive p...

OBJECTIVE To review and assess the current published literature regarding the efficacy of surgical management of sialorrhea in pediatric patients. DATA SOURCES The MEDLINE database was systematically reviewed for articles reporting on the use of surgical procedures to treat sialorrhea published from January 1, 1963, to November 30, 2008. STUDY SELECTION Inclusion criteria included presence ...

INTRODUCTION To evaluate the efficacy and adverse effects of repeated onabotulinumtoxinA (BoNT-A) treatment in patients suffering from Parkinson's disease (PD) with sialorrhea. METHODS A retrospective analysis of 16 patients with sialorrhea treated with BoNT-A at our movement disorders outpatient clinic was conducted from February 2009 to September 2013. A patient with adult cerebral palsy an...

Sialorrhea may present as a troublesome symptom in patients suffering from Parkinson's disease. Current options for treatment include anticholinergic drugs, irradiation, surgery, oral-motor and behavioural therapies, and injection of botulinum neurotoxin (BoNT) in the salivary glands. The aim of this study is to evaluate the safety and administration of BoNT as a treatment for sialorrhea in pat...