Here we introduce metaseq, a software library written in Python, which enables loading multiple genomic data formats into standard Python data structures and allows flexible, customized manipulation and visualization of data from high-throughput sequencing studies. We demonstrate its practical use by analyzing multiple datasets related to chromatin insulators, which are DNA-protein complexes pr...

Background: Improvement of attitudes toward breast cancer positively affects the screening behaviors of women. Imagery has been shown to have a positive impact on the screening behaviors of women. Aim: This study aimed to investigate the effects of breast cancer screening training based on the systematic comprehensive health education and promotion (SHEP) model on the attitudes and breast self-...

BACKGROUND The Systolic Hypertension in the Elderly Program (SHEP) demonstrated the benefit of treating isolated systolic hypertension (ISH) in older adults. However, nearly 20% of older adults remain at high risk of heart disease and stroke from untreated ISH. METHODS For the Pittsburgh SHEP cohort, 11- to 14-year death or cardiovascular event rates were compared for active (n = 135) and pla...

Recruitment is always among the major challenges faced in a clinical trial. A wide variety of strategies must be used to ensure adequate enrollment of the study cohort. Recruitment for the Systolic Hypertension in the Elderly Program (SHEP) posed unique problems, so numerous strategies were developed for contacting and screening large numbers of older individuals. The older population is the mo...

Previously synthesized poly(methacrylic acid-co-cholesteryl methacrylate) P(MAA-co-CMA) copolymers were examined as potential drug delivery vehicles. P(MAA-co-CMA) copolymers were fluorescently labelled and imaged in SHEP and HepG2 cells. To understand their cell internalization pathway endocytic inhibition studies were conducted. It was concluded that P(MAA-co-CMA) are taken up by the cells vi...

Rigorous principles ' shall govern the approaches to analyzing data in the Systolic Hypertension in the Elderly Program (SHEP). In particular, analyses shall adhere to the "intention-to-treat rule," that is, randomized patients shall remain in their assigned treatment group regardless of the treatment actually received. The primary end point in SHEP is the occurrence of fatal or nonfatal stroke...

The mitochondrial peripheral benzodiazepine receptor (mPBR) is involved in a functional structure designated as the permeability transition pore, which controls apoptosis. Binding of Fas/APO-1/CD95 triggers a prototypic apoptosis-inducing pathway. Using four different human tumor cell lines (T-cell Jurkat, neuroblastoma SHEP, osteosarcoma 143N2, and glioblastoma SNB79 cell lines), all of which ...

Isolated systolic hypertension (ISH) is present in the majority of persons who reach the age of 80 years, and is caused directly or indirectly by stiffening of the aorta and large central elastic arteries. Until recently, there was no consensus on whether or not persons over 80 should be treated, according to principles established for the younger group examined in the Systolic Hypertension in ...

This research aims to describe the strategy of having a master's in implementing Cambridge curriculum shep student’s potential compete globally at SMP Thursina Internasional Islamic Boarding School Malang. The focuses study involve (1) characteristics students’ for international competitions. (2) from hand master establish students competing Globally. (3) model headmaster findings show that 1) ...