The steroid 5alpha-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.

objective: there are several factors, like environmental agents, neurotrophic factors, serotonin and some hormones such as estrogen, affecting neurogenesis and neural differentiation. regarding to importance of proliferation and regeneration in central nervous system, and a progressive increase in neurodegenerative diseases, cell therapy is an attractive approach in neuroscience. the aim of the...

background and aim: it is well - known that sex hormones regulate bone metabolism. sex steroids increase osteoblasts activities and affect growth, remodeling and bone homeostasis. the aim of this study was to examine the effects of sex hormones deficiency on craniofacial growth in rats. methods & materials: fifty, thirty–day–old wistar rats comprised the sample in this experimental study. 25 ma...

In 1936, Eugen Steinach and colleagues published a work that brought steroid biochemistry to the study of sexual behavior and, using synthetic androgens and estrogens, foreshadowed by an astonishing 4 decades the discovery of the central role of estrogen in the sexual behavior of male rats. We offer an English translation of that paper, accompanied by historical commentary that presents Steinac...

conclusions exposure to formaldehyde vapor can destroy testicular structure and decrease percentages of sperm count and progressive motility. the present study indicated that a reduction in the percentage of progressive motile sperm may be potentiated by noise (700-5700 hz) in the simultaneous exposure to formaldehyde and noise group. thus, it can be anticipated that simultaneous exposure to fo...

Neurophysiological and behavioral development is particularly complex in adolescence. Youngsters experience strong emotions and impulsivity, reduced self-control, and preference for actions which offer immediate rewards, among other behavioral patterns. Given the growing interest in endocrine effects on adolescent central nervous system development and their implications on later stages of life...

This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual orientation, reproductive and metabolic programming, and the neuroendocrine mechanism involved in the development of polycystic ovary syndrome phe...