abstract background: childhood leukemia, the most common type of cancer in children and teens, is a cancer of the white blood cells. as antioxidants can promote immune system against all types of cancer, the aim of this study was to explore the metabolic regulation and anti-oxidative effect of sesquiterpen-rich extract of ferula asafoetida (fa) on children with leukemia. materials and methods: ...

Thapsigargin (TG) is a sesquiterpen lactone that inhibits the endoplasmic reticulum (ER) calcium ATPases to disrupt calcium homeostasis and consequently induces ER stress. We have previously reported that TG induces apoptosis by engaging the death receptor 5 (DR5) and the intrinsic pathways. Second mitochondrial-derived activator (Smac) is an important modulator of apoptosis that induces activa...

Considering the easy contagion of tuberculosis (TB) disease spread and the emergence of multidrug-resistant TB, which directly impacts the failure of therapeutic goals and mortality rates increasing, TB disease control remains to be the main concern of continuous health development effort. Therefore, the discovery of new TB drug is needed. This research assessed the new natural anti-TB drug fro...

Purpose: To evaluate the ethanol extracts of the flowers, leaves, and stems of Centaurea tchihatcheffii Fischer & C.A. Meyer (Asteraceae) for their anti-inflammatory and analgesic activities in male Swiss albino mice. Methods: For the evaluation of anti-inflammatory activity, hind paw oedema was induced in the mice with carrageenan and prostaglandin-E2 (PGE2 ) and the mice received either 100 a...

Kulit jeruk manis merupakan limbah yang memiliki nilai jual tinggi dan dapat di manfaatkan kembali. kulit menghasilkan minyak atsiri. Minyak atsiri dihasilkan digunakan pada industri kecantikan parfum sebagai komponen utama. Komponen – adalah terpen, sesquiterpen, aldehida, ester, sterol 3. Penelitian bertujuan untuk dari ekstrak agar pengganti sintetik lilin aromaterapi. Bahan baku dalam penel...

Abstract Background: Childhood leukemia, the most common type of cancer in children and teens, is a cancer of the white blood cells. As antioxidants can promote immune system against all types of cancer, the aim of this study was to explore the metabolic regulation and anti-oxidative effect of sesquiterpen-rich extract of Ferula Asafoetida (FA) on children with leukemia. Materials and Met...

Background and objectives: Interaction of compounds with ct-DNA can affect the replication, protein synthesis and cell division. Different species of the genus Ferula (Apiaceae) have shown various biomedical applications for many centuries. Biological features of this genus such as cytotoxicity, antibacterial, antiviral, P-glycoprotein (P-gp) inhibitory and antiinflamm...

Die fermentative Ganzzellproduktion in Escherichia coli ermöglicht die Produktion komplexer Naturstoffe, wie Terpene, aus einfachen, günstigen und nachhaltigen C-Quellen. Ziel der Arbeit war es, einen solchen Prozess zur Synthese von Presilphiperfolan-8β-ol (PSP) zu entwickeln. Der Biosyntheseweg dieses tricyclischen Sesquiterpenalkohols konnte erfolgreich E. eingebracht werden. resultierende M...