Background: Iron is an essential mineral for normal cellular physiology but its ‎overload can lead to cell injury. For many years, deferoxamine injection has been used ‎as an iron chelator for treatment of iron overload. The aim of this study is to compare ‎oral deferoxamine, activated charcoal, and vitamin C, as an absorbent factor of Fe, in ‎changing the serum level of iron in iron overload r...

Parkinson disease is one of the neurodegenetive disease with a prevalence of about 1% in people older than 65.from a pathological point of view,degeneration of neuromelanin cells in pars compacta of substantia nigra has been established.the reason of degeneration is unknouwn.increase in iron concentration in substantia of parkinson,s patients has been established.the  increase of iron in this p...

background: early childhood caries (ecc) is a virulent form of dental caries that can destroy the primary dentition of preschool children. the purpose of this study was to investigate a possible association between ecc with serum iron and serum ferritin levels. materials and methods: following the ethical approval, 204 children aged 24–71 months were recruited for a double-blind, randomized cro...

although, iron depletion is a common disorder among athletes, little data exist regarding the effect of gymnastic training on iron status. the objective of this study was to evaluate the effect of gymnastic exercise on body iron status and hematologic profile. the present investigation involved 35 male gymnasts aged from 6 to14 yrs. serum ferritin level, total iron binding capacity (tibc), iron...

Background: Iron can causes lipid peroxidation in vivo and in vitro. Iron  promotes myocardial injury in experimental animals. Low Density Lipoprotein (LDL) oxidation by oxidants including iron have a central role in atherosclerotic process. By this means, evaluation of serum iron in patients with coronary artery disease (CAD) has a significant importance. Materials and Methods: In this cross s...

background oxidative stress plays a major pathogenic role in liver injury following chronic hepatitis b. glutathione peroxidase (gpx) has a central role in regulating the oxidative state. hepatitis b virus (hbv) results in down-regulation of gpx. on the other hand, iron homeostasis is disrupted in hbv infected patients. therefore, the objective of this study was to assess the interplay of gpx a...

PURPOSE Excessive brain iron accumulation contributes to cognitive impairments in hepatitis B virus (HBV)-related cirrhotic patients. The underlying mechanism remains unclear. Hepcidin, a liver-produced, 25-aminoacid peptide, is the major regulator of systemic iron metabolism. Abnormal hepcidin level is a key factor in some body iron accumulation or deficiency disorders, especially in those ass...

trichuriasis is an intestinal parasitic disease which is caused by trichuris trichiura, a soil transmitted helminth. in order to evaluate the iron status of trichuriasis in patients a total of 120 (49 males and 71 females) cases with trichuris trichiura as well as 54 healthy individuals were evaluated. blood samples were analyzed for serum iron, transferrin saturation percent, haemoglobin and o...

Abstract Objective Thalassemia major is a severe transfusion-dependent anemia that needs iron chalation therapy to remove iron overload. The objectives of the present study were to assess the iron overload liver response to inulin of chicory supplementation by evaluating the serum ferritin and liver enzymes. Methods Among 70 beta thalassemia patients, 50 were selected for chelating therapy ...