A test kit (Iso-ALP, Boehringer Mannheim) for measuring human bone alkaline phosphatase activity in serum or plasma was evaluated in five laboratories in three countries. The assay is based on the principle described by Rosalki and Foo (Clin Chem 1984;30:1182-6) and uses wheat germ lectin to precipitate bone alkaline phosphatase. Residual ALP in the supernate in comparison with total ALP is use...

It is well known that the individuals with different Mizaj (Temperament) have different morphological features and different psychological profiles. However, very little is known about the variations in their physiological capacities and the variations in their normal values of biochemical substances in the body. In this study, level of enzyme alkaline phosphatase in serum was estimated in 52 h...

Bone-specific alkaline phosphatase (BAP) synthesized by osteoblasts is a highly sensitive and specific marker of the boneforming activity. Paget’s disease is the most common cause of elevated serum BAP. Other causes include osteomalacia, rapid bone loss, bone growth, healing fracture, acromegaly, hyperthyroidism, osteogenic sarcoma, bone metastases, leukemia, myelofibrosis, and rarely myeloma. ...

BACKGROUND Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function. CASE PRESENTATION Here, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) during LEV monotherapy. Moreover, the serum ALP level was surprisingly decreased to normal after LE...

To characterize serum constituents in blood in response to cold exposure, we measured serum inorganic phosphate (Pi) and alkaline phosphatase (ALP) levels. After 30 min exposure of cold, the serum Pi and alkaline phosphatase levels were 3.4 ± 0.06 mg/l and 72.33 ± 0.45 μmole/l respectively where as the control levels of these constituents are 3.05 ± 0.03 mg/l and 84 μmole/l respectively. Cold e...

Alkaline phosphatase (ALP, 3.1.3.1) is a dimeric glycoprotein present in humans that catalyses the hydrolysis of orthophosphoric monoesters at alkaline PI! (1). It has been reported to occur in abundance in human bile canaliculi, bone, intestine, placenta and kidney (1). Hence serum ALP levels has been extensively used as a diagnostic tool for hepatobilliary disorders particularly in patients w...

Serum alkaline phosphatase (ALP) concentration is a prognostic factor for osteosarcoma in multiple studies, although its biological significance remains incompletely understood. To determine whether gene expression patterns differed in osteosarcoma from patients with differing serum ALP concentrations, microarray analysis was performed on 18 primary osteosarcoma samples and six osteosarcoma cel...

Hepatomegaly is a common finding in primary myelofibrosis (PMF), mostly due to extramedullary hematopoiesis, as demonstrated by liver biopsies in previous studies, and high serum alkaline phosphatase (ALP) is usually the most frequent associated biochemical abnormality. In the current study, we examined the clinical, prognostic and molecular correlates of increased ALP and aspartate aminotransf...

BACKGROUND Currently, the best resources for assessment of bone tissue using imaging techniques are expensive and available in few medical facilities, thus serum or urinary bone turnover biomarkers could be useful as early indicators of prognosis. However, there is a wide range of variability in bone turnover markers due to several factors, such as different ages and metabolic stages, thus it i...

conclusions the elevation of hmw-alp activity in cu treated animal suggests the occurrence of biliary disease. this may be used as a biomarker for the diagnosis of copper toxicity. results obtained data showed that with increasing administration of copper, the alp activity was elevated significantly. in comparison with the control group the elevations were between 20%-56% using gel filtration c...