It has been suggested that vitamin D contributes not only to bone mineral metabolism but also to important other physiological processes. Vitamin D levels have been associated with increased mortality in predialysis and incident HD patients, but no data is available on the association between vitamin D levels and survival in prevalant hemodialysis (HD) patients. Five hundred and forty five prev...

To the Editor: In an article of 2007 about vitamin D deficiency, it was reported that low 25OH-vitD (25hydroxyvitaminD) plasma levels are found in thyrotoxicosis, with thyrotoxicosis being the last in the list of acquired causes of vitamin D deficiency (1). We first demonstrated low 25OH-vitD plasma levels in thyrotoxicosis (2), as well as the fact that the transformation of vitamin D into 25OH...

BACKGROUND Vitamin D testing is increasing worldwide. Recently several diagnostic manufacturers including Abbott and Siemens have launched automated 25-hydroxy vitamin D (25OH-D) immunoassays. Furthermore, preexisting assays from DiaSorin and Roche have recently been modified. We compared the performance of 5 automated immunoassays, an RIA and 2 liquid chromatography-tandem mass spectrometry (L...

The problem of vitamin D deficiency during intensive care requires a number of clarifications. Initially, it is essential to focus on the fundamentals of vitamin D status assessment. Total 25-hydroxyvitamin D (25OH-D) is currently considered as the best indicator of vitamin D status. Due to practical reasons (less knowledge needed, higher throughput), immunoassays are generally preferred to mea...

Objective—Hypothesizing that levels of 25OH-D in body fluids are reflective of vitamin repletion status, we aimed to determine if 25OH-D levels in the follicular fluid (FF) of infertile women undergoing in vitro fertilization (IVF) demonstrate a relationship with IVF cycle parameters and outcome. Design—Prospective Cohort study Setting—Academic tertiary care center Patients—84 infertile women u...

OBJECTIVE: There is increasing evidence that vitamin D can be protective against the development of multiple sclerosis (MS), but it may also be beneficial for the clinical course of the disease. Our objective was to prospectively investigate if 25-hydroxy-vitamin D (25OH-D) levels are associated with exacerbation risk in MS in a study with frequent serum measurements. METHODS: This was a prospe...

There have been methodological problems for studying hypovitaminosis D and K in the elderly. First, studies were done either by evaluating food intake or measuring their circulating levels, but rarely by both in Japan. In this paper, vitamin D and K intakes and their circulating levels were simultaneously determined. Second issue is whether hypovitaminosis D and K are independent of general mal...

Background: Epilepsy is a chronic condition with an incidence of 4–10/1,000 worldwide, Antiepileptic drugs (AED) in common use are carbamazepine (CBZ), phenytoin (DPH), phenobarbitone (PB), and sodium valproate. The effect of AEDs on the vitamin D metabolism is of considerable value especially in children. There are few clinicians who use prophylactic calcium or vitamin D for patients taking AE...

OBJECTIVES To clarify potential differences between denosumab (DNS) and bisphosphonates (BIS) in terms of bone density and bone metabolism, in a sample of postmenopausal women. METHODS A total of 113 postmenopausal women aged 53-66 years were treated with either DNS or BIS for 12 months. Bone densitometry and laboratory tests were compared between baseline and follow-up. RESULTS Femoral nec...