Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working swine industry. S. express capsular polysaccharides (CPS) a major bacterial virulence factor that define serotypes. Oligosaccharides resembling CPS serotypes 2, 3, 9, 14 have been synthesized, glycans related to 2 9 were placed on glycan array surfaces screen blood f...

Clinical use of the 7-valent pneumococcal protein conjugate (PCV7) vaccine, which includes serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F, dramatically reduced invasive pneumococcal disease (IPD); however, the effectiveness was diminished due to serotype shift. Although shift due to known serotypes was anticipated, shift by misidentified serotypes was unexpected. We describe the experience with new...

background: identifying regional types and evaluating the frequency of pneumococcal strains has become increasingly important especially in vaccination. the purpose of this study was the identification and frequency determination of our regional serotype and evaluation of the performance of recent type specific multiplex pcr for the diagnosis of streptococcus pneumonia serotypes. methods: all i...

aim : the purpose of this study was to characterize phenotypically and genotypically the serotypes of the e. coli o111 associated with diarrheal disease and assess the variation among serotypes in terms of specific virulence factors and hela cells adherence patterns. background : escherichia coli o111 serogroups are prevalent in endemic or sporadic cases of diarrhea, especially in developing ar...

Australia has a universal infant pneumococcal conjugate vaccination program and until recently polysaccharide vaccine for non-Indigenous adults aged ?65 years Indigenous ?50 years. We documented the impacts of adult programs on epidemiology invasive disease (IPD) in adults. IPD notifications from National Notifiable Disease Surveillance System were analysed 2002 to 2017, grouped by age, serotyp...

We developed a multiplex PCR-based reverse line blot (mPCR/RLB) assay to identify 50 uncommon pneumococcal serotypes. In combination with a previously described mPCR/RLB assay (3), all 90 pneumococcal serotypes can be identified individually (32 serotypes) or, because of predictable cross-reactions, to within small groups of two to five related serotypes (58 serotypes), which can be distinguish...

The currently available 7-valent pneumococcal conjugate vaccine (PCV7) elicits good immune response to and is effective against vaccine serotypes. However, its effectiveness against vaccine-related serotypes is variable. Serum samples were obtained 1 month after the last vaccination from 31 infants immunized with PCV7 at 2, 4, and 6 months of age. The sera were used to determine immunoglobulin ...

Streptococcussuis is an important zoonotic agent causing severe diseases in pigs and humans. To date, 33 serotypes of S. suis have been identified based on antigenic differences in the capsular polysaccharide. The capsular polysaccharide synthesis (cps) locus encodes proteins/enzymes that are responsible for capsular production and variation in the capsule structures are the basis of S. suis se...

Streptococcus pneumoniae is one of the common causes disease in children like pneumonia, otitis and meningitis. Pneumococci colonize asymptomatically nasopharynx could cause severe life-threatening illnesses. Since 2010, 10-valent pneumococcal conjugate vaccine (PCV-10) has been included Bulgaria for routine immunization from 6 weeks to 2 years. For period 2011-2019 coverage with it considered ...