BACKGROUND In vitro studies suggest that mediators of systemic inflammatory response syndrome are generated in the course of hemolytic transfusion reactions. Evidence for the in vivo significance of these findings is given by the present clinical and laboratory analysis of a severe delayed hemolytic transfusion reaction (DHTR). CASE REPORT A 67-year-old patient (blood group O, D-negative) wit...

Severe sepsis and septic shock represent a major healthcare challenge. Much of the improvement in mortality associated with septic shock is related to early recognition combined with timely fluid resuscitation and adequate antibiotics administration. The main goals of septic shock resuscitation include intravascular replenishment, maintenance of adequate perfusion pressure and oxygen delivery t...

Introduction RBCT is still a subject of debate with 2 main questions: what is the optimal threshold? and does transfusion impact the outcome?. Concerning septic patients, a threshold of 10 g/dL was for many years the objective during the first hours of septic shock and since the last surviving sepsis campaign, a threshold of 7 g/dL for stabilized septic patients is proposed. Nevertheless, the e...

OBJECTIVE To evaluate the immediate effects of red blood cell transfusion on central venous oxygen saturation and lactate levels in septic shock patients with different transfusion triggers. METHODS We included patients with a diagnosis of septic shock within the last 48 hours and hemoglobin levels below 9.0 g/dL Patients were randomized for immediate transfusion with hemoglobin concentration...

The risks of transfusion remain significant. Familiarity with the incidence, etiology, management, and prevention of commonly encountered transfusion reactions is integral to the practice of transfusion medicine. This review intends to serve as a practical guide reflecting the current understanding of adverse transfusion events, clinical features helpful for diagnosis, and recommended managemen...

BACKGROUND Early goal-directed therapy has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy among patients presenting with severe sepsis or septic shock. But more importantly, early goal-directed therapy also became standard care for non-septic critically ill patients and was adopted for high-risk surgical patients. DISCUSSION Importantly, transfusion of red ...

Synonyms and related keywords: blood transfusions, blood products, acute hemolytic transfusion reactions, transfusion complications, blood product reactions, allergic transfusion reaction, blood type, circulatory volume overload, anaphylactic transfusion reaction, blood anaphylaxis, hemolytic reactions, allergic reactions, anaphylactic reaction, anaphylaxis, transfusion-related acute lung injur...

BACKGROUND Treating anaemia with red blood cell (RBC) transfusion is frequent, but controversial, in patients with septic shock. Therefore we assessed characteristics and outcome associated with RBC transfusion in this group of high risk patients. METHODS We did a prospective cohort study at 7 general intensive care units (ICUs) including all adult patients with septic shock in a 5-month peri...