Background Sepsis is common in cirrhosis and often a result of immune dysregulation. Specific stimuli pathways inter-cellular communications between cells sepsis are incompletely understood. Immune cell-derived extracellular vesicles (EV) were studied to understand mechanisms cirrhosis. Methods EV measured patients [Child-Turcotte-Pugh (Child) score A, n = 15; B 16; C 43 Child-C with (n 38)], h...

First six cases of neonatal group B B haemolytic streptococcal sepsis in GHKL & Maternity Hospital K.L. were reported and in one third, it was fatal. Five of the cases were 'early onset' type and one was 'late onset' type. While maternal infant transmission of the disease is important in the 'early onset' type, environmental sources of infection are also significant. No gestational age or birth...

signaling amp-activated protein kinase (ampk), an energy sensing enzyme, has been implicated in controlling inflammation. in this study we investigated whether activation of ampk by metformin could protect the lung from lipopolysaccharide (lps)-induced acute injury by inhibitingng tlr4 pathway. male wistar rats were randomly divided into 3 groups (n=6): control group received normal saline (0.5...

background management of bacterial sepsis as a common cause of hospitalization and a life threatening clinical syndrome is a challenge. in previous studies, incorrect diagnosis of sepsis and unnecessary treatment have been frequently reported. objectives the aim of this study was to evaluate the diagnosis and treatment of cases with a primary diagnosis of sepsis. patients and methods of 410 med...

Various coagulation tests like Prothrombin Time (PT) and Activated Partial Thromboplastin (APTT) are estimated by automated analyzers. The newer fully analyzers generate clot wave forms aPTT-CWA for these parameters derived. In this study, the objective was to analyze form characteristics morphology its first second derivative values in cases with abnormal APTT. ACL TOP 300 generated curves APT...

Legionnaires’ disease caused by the bacteria Legionella pneumophila, is considered a type of atypical pneumonia. The usually presents with dyspnea, cough, fever, muscle aches, headache, nausea, and vomiting. A milder form (Pontiac fever) flu-like illness also exists. In addition to lung infection, extrapulmonary manifestations might occur including sepsis, rhabdomyolysis, neurological impairmen...

Background: The mortality rate of sepsis and pneumonia is higher in end-stage renal disease (ESRD) patients than in the general population. Bacterial infections are the most common cause of hospitalization in dialysis patients and the most common source of bacteremia is vascular access in these patients. The aim of this study was to determine the prevalence of infectious causes of hospitalizati...

conclusions the results of this study indicated that patients with sepsis had lower serum vitamin d levels than healthy controls. also, patients with more severe disease had lower serum vitamin d levels, but to evaluate causation and determine whether vitamin d supplementation could be effective in reducing the risk or severity of sepsis, randomized controlled trials should be conducted. result...