background: multiple severity scoring systems have been devised and evaluated in adult sepsis, but a simplified scoring model for pediatric sepsis has not yet been developed. this study aimed to develop and validate a new scoring model to stratify the severity of pediatric sepsis, thus assisting the treatment of sepsis in children. methods: data from 634 consecutive patients who presented with ...

Background: Early diagnosis of neonatal sepsis is quite challenging. I/T ratio (immature to mature neutrophil ratio) is a highly sensitive marker of sepsis but is time-consuming and subjective. Off late, volume conductivity and scatter (VCS) of neutrophils are among the newer parameters available for screening a septic neonate. This study aimed to determine the correlation between the I/T ratio...

  Septicemia in neonates is the commonest cause of mortality. Early recognition and diagnosis of neonatal sepsis remains a challenge because of the variable and nonspecific clinical presentation. The laboratory criteria are often non specific and not fully reliable. The objective of this review is to highlight the various hematological and biological markers of neonatal sepsis. We searched ...

background it is known that risk factors related to neonatal bacterial sepsis are complex. objectives the current study aimed to determine the risk factors of neonatal sepsis. materials and methods this study was conducted on 1023 neonates admitted to neonatal intensive care units (nicus) in south sinai governorate hospitals from january 2010 till september 2014. demographic data of the neonate...

conclusions sepsis enhances the production of plasma ngal in critically ill neonates. thus plasma ngal can help clinicians diagnose sepsis in critically ill neonates during early phases. results the ngal levels were significantly higher in septic neonates compared with non-septic neonates (102.9 ± 69.9 ng/ml versus 29.2 ± 13.3 ng/ml, p value = 0.0001). an optimal cut off-point of 48 ng/ml for s...

To explore the favourable functions of polysaccharide from Spirulina platensis (PSP) on sepsis-originated acute lung injury, together with corresponding mechanisms. 60 male SD rats were randomly separated into sham, sepsis, and sepsis+PSP group 20 in each group. Sepsis rat model was constructed by cecal ligation puncture (CLP). The mortality sepsis-related symptoms used to judge success. CLP su...

sepsis constitutes an important cause of hospital admission with a high mortality rate. appropriate antibiotic therapy is the cornerstone of therapy in patients with sepsis. although numerous studies have recommended early antibiotic initiation in severe sepsis or septic shock stages of sepsis syndrome, its role in treatment of patients with sepsis who have not entered these stages remains to b...

discussion l. monocytogenes can cause progressive and rapidly fatal infections in the vulnerable persons, with multisystem involvement. since this bacterium is not susceptible to cephalosporines, it will be better to consider effective antimicrobials in the treatment of the possible cases. case presentation a 70-years-old patient with chronic renal failure was admitted to the infectious disease...

background: to determine prospectively the prevalence of anaerobic and aerobic infection in early onset (during 72 hours of age) neonatal sepsis, in tehran vali-e-asr hospital. methods: among all the live birth, neonates suspecting of having septicemia were investigated for isolation of micro­organisms. culture bottle containing enriched tryptic soy broth was used for standard blood culture sys...