Many patients with depression have comorbidities associated with an impairment of sensorimotor gating, such as e.g. schizophrenia, Parkinson Disease, or Alzheimer disease. Anti-depressants like clomipramine that modulate serotonergic or norepinephrinergic neurotransmission have been shown to impact sensorimotor gating, it is therefore important to study potential effects of clomipramine in orde...

Background: Diabetic peripheral sensorimotor neuropathy is one of the most prevalent neuropathic syndromes affecting around 50 % people with diabetes. Its development gradual subtle changes hence ignored. Early diagnosis using simple bedside tools essential. Methods: The prospective study evaluation in diabetes involved examination 500 diabetic patients for neuropathy. Pinprick, vibration sensa...

PURPOSE Diffuse tissue damage from impact or blast traumatic brain injury (TBI) degrades information processing throughout the brain, often resulting in impairments in sensorimotor function. We have developed an eye-movement assessment test, consisting of a simple, appropriately randomized, radial tracking task together with a broad set of oculometric measures that can be combined to yield a se...

Objective To determine whether impairments across cognitive and affective domains provide additional information to sensorimotor deficits for fall prediction among various populations. Design We pooled data from 5 studies this observational analysis of prospective falls. Setting Community or low-level care facility. Participants Older people (N=1090; 74.0±9.4y; 579 female); 500 neurologically i...

Does sensorimotor dysfunction underlie reading impairment? To investigate this question, a battery of literacy, phonology, auditory, visual, and motor tests were administered to age- and ability-matched groups of dyslexic, autistic, and control children. As in previous studies, only a subset of the dyslexic children had sensory and/or motor impairments, whilst some dyslexics were entirely spare...

OBJECTIVE Most rehabilitative interventions following stroke emphasize the improvement of motor deficits but rarely address sensory function and sensorimotor control. We report here a case of cerebral infarction localized to the postcentral gyrus that presented with severe impairment of motor control due to profound proprioceptive sensory loss. We attempted to demonstrate the mechanism for the ...

BACKGROUND AND PURPOSE Quantitative data on sensory impairment in stroke patients are limited. We measured the perception thresholds for temperature and thermal pain in patients with different lacunar syndromes, correlated the results with clinical and magnetic resonance imaging (MRI) findings, and studied the long-term prognosis of sensory dysfunction. METHODS Quantitative thermal testing wa...

INTRODUCTION Over the last years, evidence has accumulated that rolandic epilepsy (RE) is associated with serious cognitive comorbidities, including language impairment. However, the cerebral mechanism through which epileptiform activity in the rolandic (sensorimotor) areas may affect the language system is unknown. To investigate this, the connectivity between rolandic areas and regions involv...

Contralesional dorsal premotor cortex (cPMd) may support residual motor function following stroke. We performed two complementary experiments to explore how cPMd might perform this role in a group of chronic human stroke patients. First, we used paired-coil transcranial magnetic stimulation (TMS) to establish the physiological influence of cPMd on ipsilesional primary motor cortex (iM1) at rest...