The release of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A (BFA) action, preceding the movement of Golgi membrane into the ER. ATP depletion also causes the reversible redistribution of the 110-kD protein from Golgi membrane into the cytosol, although no Golgi disassembly occurs. To further define the effects of BFA on the association of the 11...

Organosilanes contain hydrocarbon-like backbones, allowing them to react with silicone-based agents in the presence of a catalyst and polymerize into membranes tunable transport mechanical properties. Owing their hydrophobicity, Poly(dimethylsiloxane) (PDMS) membranes, more particularly, Sylgard™ 184, have been used for applications including drug delivery, gas separation, microfluidics fabrica...

In 1973, experimental evidence was reported in support of the view that water polarized in multilayers rather than simple lipid is responsible for the semipermeable properties of living cell membranes. The present article presents a full rebuttal to a subsequent attack on that view.

Rat islets encapsulated in alginate-polylysine membranes were implanted intraperitoneally into nonimmunosuppressed streptozocin-induced diabetic mice. Diabetes was reversed within 3 days, and the animals remained normoglycemic for up to 144 days, with a mean xenograft survival of 80 days. This was significantly greater than nonencapsulated islets, which functioned for <14 days. The graft surviv...

Semipermeable silastic rubber membranes can be used to diffuse focally a variety of chemicals including antitumour drugs. Of the eight drugs tested, in vitro tests showed the best diffusion with dactinomycin, mithramycin, and oncovin, and the poorest diffusion with bleomycin, fluorouracil, and thiotepa. Biological testing was performed with mithramycin, dactinomycin, and oncovin using tissue cu...

Inside Front Cover: Poly(vinyl alcohol)-b-poly(styrene) copolymer (PVA-b-PS) self-assembles in solution, and after coating drying, it forms a semipermeable self-assembled membrane, as demonstrated by Wilfredo Yave co-workers article number 2200875. PVA is the permeable matrix PS acts an impermeable nanodomain. The design of this tailor-made block eliminates use chemical cross-linkers acid catal...