Two members of a placental alkaline phosphatase (PLAP) family, PLAP and PLAP-like or germ cell alkaline phosphatase, are aberrantly expressed in tumors of ecotropic origin. To characterize alkaline phosphatase induced in seminoma, alkaline phosphatase cDNA clones were isolated from a cDNA library constructed from seminoma cells and characterized by nucleotide sequence determination. Thus, isola...

BACKGROUND Seminomas in the dog have traditionally been assumed to resemble human spermatocytic seminomas, based on their low malignancy and high occurrence in old individuals. However, recently published studies indicate that canine seminomas can be classified as classical and spermatocytic seminomas in a similar way as in man, and that classical seminomas comprise a substantial proportion of ...

malignant germ cell tumors, and it most frequently occurs in the anterior mediastinum in the chest (1). The posterior mediastinum is a rare site of origin for seminoma, and prominent cystic change of a posterior mediastinal seminoma has not been previously described. The present report describes the CT, MR and F-FDG PET/CT findings of a case of a primary posterior mediastinal seminoma that was ...

Seminoma is the most frequent carcinoma of the testicle in the fourth decade of life and constitutes 60% to 65% of germ cell neoplasia [2]. Several histopathological characteristics of the tumor have been evaluated and three types of pure seminoma have been described: classic, anaplastic and spermatocytic [3]. We report a patient with seminoma arising in an undescended testis which presented as...

Clusterin expression has a positive correlation with the occurrence and progression of various types of tumors from different genetic backgrounds. Cluster in overexpression may protect tumor cells from apoptosis and damage caused by autoimmunity or anti-tumor therapy. Using immunohistochemisty, one previous study showed that clusterin protein expression is down-regulated in human testicular sem...

A xenograft line, HX 53, has been established in immune-suppressed mice from a specimen of a lymph node metastasis in a patient with a histological diagnosis of seminoma but with markedly raised circulating levels of alpha-fetoprotein. Histological, immunocytochemical, and ultrastructural studies of this xenograft line have suggested that a solid variant of yolk sac carcinoma may exist, which m...

BACKGROUND The route of local and metastatic spread of testicular seminoma is well recognised and accepted. The spread is via lymphatics to the paraaortic nodes. CASE PRESENTATION We present a case report of testicular seminoma in a 56 year old man with previously unreported histological findings. In this case seminoma tumour cells did not appear to have spread by the expected lymphatic route...

Between 1979 and 1996 303 men with stage I testicular germ cell tumours (120 seminoma and 183 non-seminomatous germ cell tumours (NSGCT)) were enrolled onto a programme of surveillance. In our institutions the frequency of computed tomography (CT) scans is reduced compared with other centres. For all 303 men, the median follow-up is 5.1 years (range: 0.1-21.7 years) and there have only been 3 d...

PURPOSE To establish a seminoma orthotopic model with lymph node metastasis to investigate the factors related to the lymphophilic behavior of seminoma cells. MATERIALS AND METHODS Testicular seminoma xenografts were established by the inoculation of small fragments from subcutaneous (s.c.) xenografts that had previously been established in severe combined immunodeficient (SCID) mice with a s...

physical agents such as ultraviolet or ionizing radiation and repetitive trauma have been related to the causation of cancer in humans. much less clear is the association between exposure to radiofrequency, such as radar and microwave radiation to the development of cancer. sporadic case reports and small series suggest that this type of radiation might lead to cancer or contribute to its evolu...