Objective: Tumor necrosis factor-alpha (TNF-a) has been shown to inhibit germ cell death in human seminiferous epithelium. In the present study, we wanted to explore the effects of TNF-a in the rat seminiferous epithelium and to study molecular mechanisms of germ cell apoptosis. Furthermore, the effects of infliximab were studied. Infliximab is a TNF-a antagonist used in autoimmune disorders, s...

Some properties of the interaction between radioiodinated human follicle stimulating hormone (lz51-hFSH) and its specific receptors in preparations of rat seminiferous tubule homogenate are described. Specific binding of lz51-hFSH by seminiferous tubule homogenate was appreciably greater than to Leydig cell homogenate of rat testes. The uptake of rz51-hFSH was hormone specific and uptake inhibi...

Background: Melatonin, the pineal gland hormone as a direct or indirect antioxidant and free radical scavenger, is involved in the process of both aging and age-related diseases. This study investigates the effects of melatonin on the histology of testicular seminiferous tubules in aged mice. Materials and Methods: Twenty male, white mice, aged 16 months, that weighed 20-23 gr were equally divi...

Introduction: Varicocele is a pathological dilation of spermatic cord vein plexus, and celecoxib, an inhibitor of cyclo-oxygenase-2, is widely used in the treatment of chronic inflammation. So, we examined the effects of celecoxib on inflammatory cytokines, testicular Sertoli and spermatogonial cells number, seminiferous tubule diameter, and sperm indices in immature male rats with induced vari...

At the Cleveland meeting of the American Association of Anatomists, (1912-1913), Curtis1 reported on wax plate reconstructions of the seminiferous tubules of the white mouse, presenting figures of a model of an entire tubule having an actual length of somewhat over 13 em. The tubule completely reconstructed presents the form of an arch, the two ends of the arch lying in close proximity, each te...

Administration of Gonadotrophin releasing hormone (GnRH) to male C versicolor during nonbreeding season increases the weight of testis;diameter of testis, seminiferous tubule, Sertoli and Leydig cell nuclei. It also activates the spermatogenic process. Increase in the weight of epididymis and lowered cholesterol level of testis indicate androgen production. Treatment of tesotsterone along with ...

The potent smooth muscle agonist endothelin-1 (ET-1) is involved in the local control of seminiferous tubule contractility, which results in the forward propulsion of tubular fluid and spermatozoa, through its action on peritubular myoid cells. ET-1, known to be produced in the seminiferous epithelium by Sertoli cells, is derived from the inactive intermediate big endothelin-1 (big ET-1) throug...

UNLABELLED The aim of this study was to assess the impact of xenoestrogens: diethylstilbestrol (DES) and zearalenone (ZEA) on rat's pubertal testis and to compare it with the effect of natural estrogen - 17beta-estradiol (E). Male Wistar rats were daily, subcutaneously injected at 5th-15th postnatal days (p.d.) with E (1.25 or 12.5 mug) or DES (1.25 or 12.5 mug) or ZEA (4 or 40 mug) or vehicle....