The recovery of signal parameters from noisy sampled data is an essential problem in digital signal processing. In this paper, we discuss the numerical solution of the following parameter estimation problem. Let h0 be a multivariate exponential sum, i.e., h0 is a finite linear combination of complex exponentials with distinct frequency vectors. Determine all parameters of h0, i.e., all frequenc...

Mycobacterium tuberculosis secretes a large number of polypeptides with broad biological and immunological functions. We describe here the characterization of a 28-kDa acid phosphatase of M. tuberculosis (SapM) localized to the culture filtrate. The mature protein demonstrated biochemical characteristics similar to those of the bacterial nonspecific acid phosphatases. However, SapM yielded sign...

An alternating method, in conjunction with the finite element method and a newly developed analytical solution for an elliptical crack in an infinite solid, is used to determine stress intensity factors for semi-elliptical surface flaws in cylindrical pressure vessels. The present finite element alternating method leads to a very inexpensive procedure for routine evaluation of accurate stress i...

Tuberculosis (TB) is responsible for nearly 1.4 million deaths globally every year and continues to remain a serious threat to human health. The problem is further complicated by the growing incidence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB), emphasizing the need for the development of new drugs against this disease. Phagosomal maturation arrest is an import...

abstract: a time domain semi-analytical solution to study thermoelastic creep behavior of  functionally graded rotating axisymmetric disks with variable thickness is presented. the rate type governing differential equations for the considered structure are derived and analytically solved. to solve these  equations, the disk is divided into some virtual sub-domains. general solution of  equilibr...

Mycobacterium bovis bacille Calmette-Guerin (BCG) provides only limited protection against pulmonary tuberculosis. We tested the hypothesis that BCG might have retained immunomodulatory properties from its pathogenic parent that limit its protective immunogenicity. Mutation of the molecules involved in immunomodulation might then improve its vaccine potential. We studied the vaccine potential o...

The mathematical modeling of the large deflections for the cantilever beams leads to a nonlinear differential equation with the mixed boundary conditions. Different numerical methods have been implemented by various authors for such problems. In this paper, two novel numerical techniques are investigated for the numerical simulation of the problem. The first is based on a spectral method utiliz...

We present isogeometric shape optimization for shell structures applying sensitivity weighting and semi-analytical analysis. We use a rotation-free shell formulation and all involved geometry models, i.e., initial design, analysis model, optimization model, and final design use the same geometric basis, in particular NURBS. A sensitivity weighting scheme is presented which eliminates certain ef...