Cholangiocarcinoma (CCA) is a malignant tumor arisen from bile duct epithelial cells. Liver fluke (Opisthorchis viverrini) infection is considered as a main cause of CCA in Northeast Thailand. Low Se intake has been found to be associated with the high risk of several cancers. The chemotherapeutic and chemopreventive potentials of several selenium compounds have been studied and proved in many ...

Selenium-enriched Cordyceps militaris fruit bodies are industrially cultivated as functional food or medicinal food in China and southeast Asia. However, composition of selenium compounds and distribution of the main bioactive components are still unknown. In the selenium-enriched fruit bodies, the main soluble selenium compounds of low molecular weight were identified as SeMet (selenomethionin...

Selenium is traditionally considered as an antioxidant element and selenium compounds are often discussed in the context of chemoprevention and therapy. Recent studies, however, have revealed a rather more colorful and diverse biological action of selenium-based compounds, including the modulation of the intracellular redox homeostasis and an often selective interference with regulatory cellula...

Organic selenium compounds have been documented to play a role in cancer prevention. Our previous study showed that selenomethionine (SeMet) induces p53 activation without genotoxic effects including apoptosis and cell cycle arrest. In this study, we investigated the mechanism by which organic selenium compounds promote p53-mediated base excision repair (BER) activity. Our data demonstrated for...

Introduction Selenium is an essential element to human health at low levels (2080 μg/L), but becomes toxic at elevated levels. Selenium exists in different forms that determine its toxicity and bioavailability. Current research is now focusing on the determination of individual selenium species or seleniumcontaining compounds. This can be done using ICP-MS as a selenium-specific detector for a ...

There are no two main-group elements that exhibit more similar physical and chemical properties than sulfur and selenium. Nonetheless, Nature has deemed both essential for life and has found a way to exploit the subtle unique properties of selenium to include it in biochemistry despite its congener sulfur being 10,000 times more abundant. Selenium is more easily oxidized and it is kinetically m...

The aim of this study was to evaluate the biological and chemical response of Allium cepa L. exposed to inorganic selenium compounds. Besides the investigation of the total content of selenium as well as its chemical speciation, the Allium test was used to evaluate the growth of onion roots and mitotic activity in the roots' meristem. The total content of selenium was determined by inductively ...

The ocular surface is strongly affected by oxidative stress, and anti-oxidative systems are maintained in corneal epithelial cells and tear fluid. Dry eye is recognized as an oxidative stress-induced disease. Selenium compound eye drops are expected to be a candidate for the treatment of dry eye. We estimated the efficacy of several selenium compounds in the treatment of dry eye using a dry eye...

Despite the current interest in selenium chemistry [1—6], oxidations by selenium dioxide remained limited to only a few classes of compounds, mainly alkenes and carbonyl compounds, in addition to some special cases [7, 8]. Selenium dioxide is the cheapest and most convenient selenium reagent, and an extension of its applications to other types of com­ pounds is therefore of considerable interes...

To the editor: It has been, currently, acknowledged that selenium, as a chemopreventive agent, reduces considerably the risk of prostate, colorectal, lung, breast or any other cancer. Furthermore, therapeutic application of selenium compounds for several advanced epithelial carcinomas has been tried through translational research. Although the anti-tumor mechanism of selenium was not entirely u...