OCD is a syndrome characterized by obsessions and compulsions, as well other neuropsychiatric features, often associated with primary psychiatric disorders various neurologic conditions. If severe, can seriously interfere the patient’s quality of life. The mainstay treatment psychotherapy, especially cognitive-behavioural therapy, pharmacologic interventions, selective serotonin reuptake inhibi...

Background Selective serotonin reuptake inhibitors (SSRIs) have been observed to drive programmed cell death in Burkitt lymphoma cells. Accordingly, they were proposed as a new modality in the treatment of Burkitt lymphoma. However, they induce apoptosis with little if any appreciable selectivity. Actually, the selectivity appears to be so low that SSRIs can also kill protozoa (such as Trichomo...

B. Understand the indications, contraindications, efficacy, use, drug interactions, and side effects of classical and newer or alternative antidepressants for treating comorbid mood or anxiety disorders in patients with pain. This would include the use of first-generation agents (e.g., tricyclics, including nortriptyline and desipramine, and monoamine oxidase inhibitors, including phenelzine), ...

Referências 1. Rowe DL. Off-label prescription of quetiapine in psychiatric disorders. Expert Rev Neurother. 2007;7(7):841-52. 2. Rachid F, Bertschy G, Bondolfi G, Aubry JM. Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases. J Clin Psychiatry. 2004;65(11):1537-45. 3. McIntyre A, Gendron A, McIntyre A. Quetiapine reduces residual depressive ...

Panic disorder is a chronic and disabling condition that is often accompanied by other psychiatric and medical conditions. The serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have been used effectively with panic disorder (PD) and conditions in which panic attacks frequently occur. Escitalopram is the most selective SSRI and a variety of evidence s...

BACKGROUND Antidepressants can impair sexual arousal. Exercise increases genital arousal in healthy women, likely due to increasing sympathetic nervous system (SNS) activity. PURPOSE Test if exercise increases genital arousal in women taking antidepressants, including selective serotonin reuptake inhibitors (SSRIs), which suppress SNS activity, and selective serotonin and norepinephrine reupt...

We investigate how the prescribing behavior of physicians reacts to scientific information and recommendations released by public authorities. Taking example antidepressant drugs, we use French panel data on exhaustive prescriptions made a representative sample general practitioners more than 110,000 depressed patients between 2000 2008. New results revealing an increase in suicidal thinking am...

Inadequate treatment response and emotional blunting are common challenges with selective serotonin reuptake inhibitors/serotonin-noradrenaline inhibitors (SSRIs/SNRIs) for major depressive disorder (MDD). We investigated the effectiveness of vortioxetine on in patients partial to SSRIs/SNRIs. Patients MDD who experienced a SSRI/SNRI monotherapy at adequate dose ?6 weeks were switched 8 10-20 m...