BACKGROUND The current practice of ingesting phytochemicals for supporting the immune system or fighting infections is based on centuries-old tradition. Macrophages are involved at all the stages of an immune response. The present study focuses on the immunostimulant properties of Tinospora cordifolia extract that are exerted on circulating macrophages isolated from CCl(4) (0.5 ml/kg body weigh...

Many plants are claimed to possess antidiabetic and antioxidant activity. In practice, it is being increasingly recognized to be an alternative approach to modern medicine. This study assess the antioxidant capacity of Tinospora cordifolia stem methanol extract in daily oral administration of 500 mg/kg of body weight for 40 days in alloxan induced diabetic rats. The erythrocytes membrane lipid ...

Objective is to investigate the effect of topical tinospora cordifolia (TC) on excisional wound in albino rats. Excisional wounds were inflicted by excising the full thickness circular skin (approximately 500 mm) from the nape of neck in albino rats under light ether anesthesia taking aseptic precautions. Treatment group received 1% tinospora cordifolia cream for 16 days from the day of woundin...

The present study was conducted to evaluate the hepatoprotective activity of different extracts of Tinospora cordifolia against carbon tetrachloride (CCl4) induced liver damage in rats. The pet ether, ethanol and aqueous extracts of various parts of the plant such as leaf, stem and root were tested at the dose of 200mg/kg body weight orally using Wistar albino rats and Silymarin was given as re...

the present study was designed to investigate the immunomodulatory activity of the ethanolic extract of tinospora cordifolia (family: menispermaceae)stem (climbing shrub, mango plant) at cellular level. for antioxidant study, the liver mitochondria were separated and the concentration of enzymes like lipid peroxidation (lpo), reduced glutathione (gsh), catalase (cat) and superoxide dismutase (s...

Seed oils of Passiflora edulis, Jatropa curucas, Tinospora cordifolia, Sesbania grandiflora and Sapindus laurifolia were investigated for their antihelmintic property against Pheritima pasthuma. Three concentrations (10, 50 and 100 mg/ml) of each oil were studied in the bioassay, which involved the determination of time of paralysis and time of death of the worm. Sesbania grandiflora showed the...

The present study was designed to investigate the immunomodulatory activity of the ethanolic extract of Tinospora cordifolia (Family: Menispermaceae)stem (climbing shrub, mango plant) at cellular level. For antioxidant study, the liver mitochondria were separated and the concentration of enzymes like lipid peroxidation (LPO), reduced glutathione (GSH), catalase (CAT) and superoxide Dismutase (S...

Tinospora cordifolia (Guduchi) is an important herb in folk and ayurvedic systems of medicine. This paper presents a critical review on chemical and biological properties of Tinospora cordifolia. Tinospora cordifolia contain various chemical constituents belonging to different classes such as alkaloids, diterpenoid lactones, glycosides and steroids. The most important biological properties repo...

The aim of the present study was to evaluate the antimicrobial activity of Tinospora cordifolia extracts against three standard ATCC strains of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The efficacy of extract was measured in terms of Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and zone of inhibition (mm). Antimicrobial activity of ...

OBJECTIVES To assess the safety and efficacy of TCE in human immuno-deficiency virus positive patients. MATERIALS AND METHODS Efficacy of Tinospora cordifolia extract (TCE) in HIV positive patients was assessed in randomized double blind placebo controlled trial. 68 HIV positive participants were randomly assigned to two groups to receive either TCE or placebo for six months. After clinical e...