The sedative effects of pentazocine 50 mg given orally have been studied in 100 healthy gynaecological patients using a standard scoring system. It was found that pentazocine produced mild sedation which was not significantly greater than that produced by a placebo in the numbers studied. The incidence of complications was low and while there was a higher incidence of postoperative nausea and v...

The ideal sedative or analgesic agent should have a rapid onset of activity, a rapid recovery after drug discontinuation, a predictable dose response, a lack of drug accumulation,and no toxicity. Unfortunately, none of the earlier analgesics, the benzodiazepines,or propofol share all of these characteristics. Patients who are critically ill experience numerous physiologic derangements and commo...

background and objective: nitric oxide (no) plays a role in thermoregulation and growth of protozoa. this work aimed to add the molecule no in physiology of protozoa in contact with abused narcotic substances. materials and methods: a sedative drug, morphine, was infused into a cell chamber containing paramecia . the cell response to the drug was recorded promptly after drug infusion using a po...

BACKGROUND Older people carry a high burden of illness for which medications are indicated, along with increased risk of adverse drug reactions. We developed an index to determine drug burden based on pharmacologic principles. We evaluated the relationship of this index to physical and cognitive performance apart from disease indication. METHODS Data from the Health, Aging, and Body Compositi...

The two main non-sedative effects of thalidomide (2-phtalimido-glutarimide) in man are the embryopathy, which finally forced termination of its use as a sedative, and the excellent efficacy in leprosy reactions, alone for whose prevention and treatment the drug is still available. Both effects can be explained on the molecular level by assuming that a non-sedative metabolite of thalidomide medi...

clonidine has sedative and analgesic properties. randomized studies examining these properties in mechanically ventilated icu patients are scarce. this study was designed to assess the impact of clonidine on sedative agent use in mechanically ventilated patients.in a prospective, randomized, double blind, placebo-controlled study in a general icu of a university medical center in tehran, iran, ...

CONTEXT Ramelteon is a novel MT1 and MT2 melatonin receptor selective agonist recently approved for insomnia treatment. Most approved insomnia medications have potential for abuse and cause motor and cognitive impairment. OBJECTIVE To evaluate the potential for abuse, subjective effects, and motor and cognitive-impairing effects of ramelteon compared with triazolam, a classic benzodiazepine s...

Anxiety disorders are widespread in general medical practice, being the reason for seeking help from doctors of various specializations. Certain difficulties diagnosis and development patient management tactics caused by variety clinical manifestations anxiety disorders. Often they associated with somatic manifestations. Benzodiazepines, antidepressants, anticonvulsants, antipsychotics, antihis...