Staphylococcus aureus is an opportunistic pathogen, commensal of the human skin and nares, but also responsible for invasive nosocomial as well as community acquired infections. Staphylococcus aureus adheres to the host tissues by means of surface adhesins, such as SdrC, SdrD, and SdrE proteins. The Sdr family of proteins together with a functional A domain, contain respectively two, three or f...

The transcriptional induction of the chicken ovalbumin gene by steroid hormones is abolished by inhibitors of protein synthesis such as cycloheximide, suggesting that a labile protein mediates this process. A steroid-dependent regulatory element (SDRE) has been identified in the 5'-flanking region of the gene between -900 and -780 that is required for induction by steroids. Additional transfect...

In this paper a nonlinear controller technique, referred to State-Dependent Riccati Equation (SDRE), is exploited to handle relative position tracking and attitude synchronization problem involving in docking manoeuvring operations between two Earth orbiting satellites. More specifically a testbed developed by DLR-Institute of Space Systems is used for testing the proposed control algorithm. Th...

The control of a satellite can be designed with success by linear theory if the has slow angular motions. However, for fast maneuvers, linearized models are not able to represent effects nonlinear terms. One candidate technique design satellite’s under maneuvers is State- Dependent Riccati Equation (SDRE). SDRE provides an effective algorithm synthesizing feedback allowing nonlinearities. Nonet...

This paper presents a detailed perspective of two constructive feedback strategies characterized by algebraic Riccati equations for solving continuous-time nonlinear deterministic optimal control problems. In each case, the system is first transformed into a linear-like, state-dependent structure. The first method is based on treating the adapted model as an instantaneously linear time-invarian...

Similar to other highly successful invasive bacterial pathogens, Staphylococcus aureus recruits the complement regulatory protein factor H (fH) to its surface to inhibit the alternative pathway of complement. Here, we report the identification of the surface-associated protein SdrE as a fH-binding protein using purified fH overlay of S. aureus fractionated cell wall proteins and fH cross-linkin...

State-dependent Riccati equation (SDRE) techniques are rapidly emerging as general design and synthesis methods of nonlinear feedback controllers and estimators for a broad class of nonlinear regulator problems. In essence, the SDRE approach involves mimicking standard linear quadratic regulator (LQR) formulation for linear systems. In particular, the technique consists of using direct paramete...

In many practical control problems the dynamics of the plant to be controlled are nonlinear. However, in most cases the controller design is based on a linear approximation of the dynamics. One of the reasons for this is that, in general, nonlinear control design methods are difficult to apply to practical problems. The State Dependent Riccati Equation (SDRE) control approach is a relatively ne...

In this report a number of algorithms for optimal control of a double inverted pendulum on a cart (DIPC) are investigated and compared. Modeling is based on Euler-Lagrange equations derived by specifying a Lagrangian, difference between kinetic and potential energy of the DIPC system. This results in a system of nonlinear differential equations consisting of three 2-nd order equations. This sys...

Purpose To evaluate long-term outcome of three years and treatment patterns of patients suffering from severely drug-refractory epilepsy (SDRE). Methods This analysis was population-based and retrospective, with data collected from four million individuals insured by statutory German health insurance. ICD-10 codes for epilepsy (G40*) and intake of anticonvulsants were used to identify prevale...