AIM To investigate the antioxidative activity of the constituents of the roots of Scrophularia ningpoensis (Chinese name: Xuanshen). METHODS The main compounds from the roots of Scrophularia ningpoensis were isolated and identified by chromatography and FABMS, NMR etc. Using the techniques of pulse radiolysis, the electron transfers from iridoid glycosides (IG) or phenylpropanoid glycosides (...

Background: Numerous plants in traditional practices of medicine have been used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer’s disease (AD) and other memory related disorders. Materials and Methods: We present here the evaluation of acetylcholinesterase (AChE) inhibitory and antioxidant activities of the aqueous methanol extracts of five traditional medic...

Article Type Research Article Authors Soufiabadi M.* PhD

Breast cancer is a prevalent malignancy among women, especially in developing countries. A large number of anticancer agents with herbal origins have been reported. Hence, herbals may play an essential role in prevention and treatment of cancers. We investigated cytotoxic effects of dichloromethane fractions of Scrophularia oxysepala extract on the MCF-7 breast cancer cell line. The cytotoxic a...

We have previously shown that scropolioside B has higher anti-inflammatory activity than catalpol does after the inhibition of nuclear factor (NF)-κB activity and IL-1β expression, maturation, and secretion. Various scropoliosides were extracted, isolated, and purified from Scrophularia dentata Royle ex Benth. We then compared their anti-inflammatory activities against LPS-induced NF-κB activit...

M. D. Garcia, M. C. Ahumada and M. T. Saenz Departamento de Farmacologfa, Facultad de Farmacia, c/Profesor Garcia Gonzalez s/n, 41012 Sevilla, Spain Z. Naturforsch. 53c, 1093-1095 (1998); received April 8/October 7, 1998 Scrophularia frutescens. Cultured H ep-2 Cells, Cultured McCoy Cells, Phenolic Acids The cytostatic activity of seven phenolic acids: coumaric, caffeic, ferulic, gentisic, prot...

Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...