This study comparatively investigated the transcriptional, physiological, and phenotypic differences of the immune disorder between severe combined immunodeficient (SCID) mouse and pig models. We discovered that the recombination activating gene-2 (Rag-2) SCID mice, but not RAG-2 SCID pigs, showed intense, infrequent, and mild cluster of CD3+-, CD4+-, and CD8+ signals respectively, suggesting t...

To develop a model of human thymus growth in vivo, we have implanted postnatal human thymus under the renal capsule of severe combined immune deficient (SCID) mice and assayed for graft survival and graft characteristics 1-3 mo after engraftment. Three groups of SCID mice were engrafted with postnatal human thymus: untreated SCID mice, SCID mice pretreated with 400 cGy of gamma irradiation 1-5 ...

Mice with the scid mutation have a defect in the V(D)J recombinase. In order to determine whether the SCID product is normally present in mature B cells that do not have the recombinase activity, scid pre-B cells were fused with myeloma cells. It was found that in the hybrid cells, a rearrangement test gene was correctly joined immediately after fusion. The same test gene was aberrantly rearran...

Although scid mice have been widely used for human HSC engraftment studies, the function of HSCs of scid mice has not been characterized. We hypothesized that the DNA repair defect of scid mice results in a stem cell defect that facilitates HSC engraftment. scid BM cells showed severely impaired repopulation potentials in the competitive repopulation assay. To assess the BM hematopoietic niche ...

This study was carried out to detect the presence of mutant alleles polysaccharide storage myopathy (PSSM) and severe combined immunodeficiency (SCID) disorders in pacing horses raised different regions Turkey. Blood/hair samples from 264 (182 Indigenous, 31 Iranian, 24 Afghan, 27 Bulgarian) aged 4 over were used. As a result study, mutation-heterozygosis (GA) GYS1 gene related PSSM disease det...

Abstract Background It is still unknown whether the “Somatic symptom disorders (SSD) and related disorders” module of Structured Clinical Interview for DSM-5, research version (SCID-5-RV), valid in China. This study aimed to assess SCID-5-RV SSD general hospital outpatient clinics Methods multicentre cross-sectional was conducted nine tertiary hospitals Beijing, Jincheng, Shanghai, Wuhan, Cheng...

As a member of the indigenous gut mucosal microbiota, segmented filamentous bacteria (SFB) colonize the guts of a variety of vertebrates and invertebrates. They are potent microbial stimuli of the gut mucosal immune system. In the small intestines of mice and rats, it has been observed that SFB are absent during the suckling period and appear in high numbers shortly after weaning, then quickly ...

PURPOSE Immunodeficient mice serve as critical hosts for transplantation of xenogeneic cells for in vivo analysis of various biological processes. Because investigators typically select one or two immunodeficient mouse strains as recipients, no comprehensive study has been published documenting differences in human tumor engraftment. Taking advantage of the increased metastatic potential of Rho...

objective: to translate the structured clinical interview for dsm-iv axisi disorders (scid-i) into persian (farsi) and to adapt this instrument for the iranian culture. method: the scid was translated into persian using an elaborate procedure to achieve a satisfactory cross-cultural equivalent. this included forward translation by bilingual (english/persian) translators, discussion and revision...