نتایج جستجو برای: sciatic nerve ligation

تعداد نتایج: 185875  

Journal: :Pain physician 2005
George Mychaskiw Jun Pan Sanjay Shah Alexander Zubkov Ben Clower Ahmed Badr John H Zhang

BACKGROUND Constriction of the sciatic nerve by loose ligation produces an inflammatory neuropathic injury. This represents an animal model for peripheral mononeuropathy. Oxygen-derived free radicals are suspected to play an important role in the pathogenesis of ischemia/reperfusion injury, leading to neurogenic inflammation. Hyperbaric oxygen (HBO) has been used anecdotally to treat clinically...

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Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Lindsey J Hudson Stuart Bevan Kara McNair Clive Gentry Alyson Fox Rainer Kuhn Janet Winter

Metabotropic glutamate receptor 5 (mGluR5) protein increased after sciatic nerve section in ipsilateral L4 and L5 DRG neuronal profiles, with most of the increase occurring in myelinated A-fiber somata. mGluR5 also increased in lamina II of the ipsilateral spinal cord and the proximal sciatic nerve stump in this model. After L5 spinal nerve ligation, mGluR5 immunoreactivity increased dramatical...

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Journal: :Life sciences 1999
L C Yu S Lundeberg H An F X Wang T Lundeberg

The present study was performed on rats with experimental mononeuropathy induced by left common sciatic nerve loose ligation. Unilateral sciatic nerve loose ligation induced decreases of the hindpaw withdrawal latency to the hot-plate test, cold-plate test and the Randall Selitto test. Sciatic nerve loose ligation induced hyperesponsiveness to touch at room temperature also. Intrathecal adminis...

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ژورنال: مجله دانشگاه علوم پزشکی فسا 2015
Bagherian Rafsanjani, M, Kazemi, A, Madahi, M, Rahmati, M, Taherabadi, J,

Background & Objectives: Painful neuropathy is a state resulting from somatosensory disease or injury. Neurotrophins such as NT-4 are crucial for neural growth and development and protect the integrity of function and structure of nervous system. Paying heed to the importance of physical activity in neural plasticity, this study focuses on the investigation of chronic effect of decreased activi...

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Journal: :Pain 2014
Peter D Drummond Eleanor S Drummond Linda F Dawson Vanessa Mitchell Philip M Finch Christopher W Vaughan Jacqueline K Phillips

After peripheral nerve injury, nociceptive afferents acquire an abnormal excitability to adrenergic agents, possibly due to an enhanced expression of α1-adrenoceptors (α1-ARs) on these nerve fibres. To investigate this in the present study, changes in α1-AR expression on nerve fibres in the skin and sciatic nerve trunk were assessed using immunohistochemistry in an animal model of neuropathic p...

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Journal: Medical Journal of Islamic Republic of Iran 2001
GR TAGHIZADEH-JAHROMI, M REZAYAT, MR ZARRINDAST,

The effect of NMDA (N-methyl-D-aspartate) receptor antagonists on tolerance to morphine antinociception was investigated in mice. Daily subcutaneous administration of 50 mg/kg of morphine hydrochloride for three days induced tolerance to different (3,6 and 9 mg/kg) test doses of morphine. The tolerance obtained was decreased by pretreatment of animals with single or repeated doses of compe...

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Journal: :medical journal of islamic republic of iran 0
gr taghizadeh-jahromi m rezayat mr zarrindast from the department of pharmacology, school of medicine, tehran university of medical sciences, tehran, i.r. iran.

the effect of nmda (n-methyl-d-aspartate) receptor antagonists on tolerance to morphine antinociception was investigated in mice. daily subcutaneous administration of 50 mg/kg of morphine hydrochloride for three days induced tolerance to different (3,6 and 9 mg/kg) test doses of morphine. the tolerance obtained was decreased by pretreatment of animals with single or repeated doses of competitiv...

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Journal: :Brain : a journal of neurology 2013
Satoshi Imai Daigo Ikegami Akira Yamashita Toshikazu Shimizu Michiko Narita Keiichi Niikura Masaharu Furuya Yasuhisa Kobayashi Kazuhiko Miyashita Daiki Okutsu Akira Kato Atsushi Nakamura Akiko Araki Kazuo Omi Masaya Nakamura Hirotaka James Okano Hideyuki Okano Takayuki Ando Hideyuki Takeshima Toshikazu Ushijima Naoko Kuzumaki Tsutomu Suzuki Minoru Narita

A multiplex analysis for profiling the expression of candidate genes along with epigenetic modification may lead to a better understanding of the complex machinery of neuropathic pain. In the present study, we found that partial sciatic nerve ligation most remarkably increased the expression of monocyte chemotactic protein 3 (MCP-3, known as CCL7) a total of 33 541 genes in the spinal cord, whi...

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Journal: :General physiology and biophysics 1984
Z Malatová M Chavko J Marsala

Activities of choline acetyltransferase (CAT) and acetylcholinesterase (AChE) were measured in several regions of the spinal cord, spinal ganglia and the sciatic nerve following ligation of the abdominal aorta just below the renal arteries for 20; 40; 80 and 120 min. Aortic ligation for 40 min produced a significant increase in the activities of both enzymes in the lumbar spinal cord. After lig...

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ژورنال: مجله علمی دانشگاه علوم پزشکی رفسنجان 2016
کاظمی, عبدالرضا,

Background and Objectives: Neuropathy is a state that resultes from nervous system disease or injury and exposes patients to the various functional complications such as decreased physical activity and its complication such as muscular and cardiovascular diseases. The purpose of the present study was determining  the chronic effect of decreased activity by spinal nerve ligation (SNL) on Tr...

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