Schistosomes, a class of parasitic trematode worms, cause schistosomiasis. Accumulating evidence suggests that microRNAs (miRNAs)-small, non-coding RNAs that are known to play critical regulatory roles in many organisms-may be involved in schistosome development and sexual maturation, as well as the pathogenesis of schistosomiasis. Schistosoma miRNAs, such as Bantam and miR-10, may be involved ...

BACKGROUND In the Philippines, the current national control strategy for schistosomiasis is annual mass drug administration (MDA) with 40 mg/kg of praziquantel in all schistosomiasis-endemic villages with a prevalence ≥10%. METHODS A cross-sectional survey of schistosomiasis was conducted in 2012 on 18 221 individuals residing in 22 schistosomiasis-endemic villages in the province of Northern...

background: schistosomiasis is one of the major communicable diseases of public health and socioeconomic importance in developing countries. this study assessed the situation of schistosomiasis among villagers of the new halfa agricultural scheme, sudan. methods: an epidemiological survey was carried out in three randomly selected residential sites: village 19, village 26 and talat shagrat camp...

schistosomiasis is the second most common parasitic cause of death, after malaria. biomphalaria glabrata is a fresh water snail with medical importance since it is the intermediate host of schistosoma mansoni, an agent of schistosomiasis. the internal defense system of b. glabrata snails is mostly represented by circulating elements of the hemolymph, hemocytes, which are important factors in fi...

Twelve Israeli travelers acquired schistosomiasis in Laos during 2002-2008, and 7 of them had acute schistosomiasis. The patients were probably exposed to Schistosoma mekongi in southern Laos, an area known to be endemic for schistosomiasis. Four possibly were infected in northern Laos, where reports of schistosomiasis are rare.

Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aim...

Abstract Background Schistosomiasis is a common helminthic infection in the tropics and subtropics, particularly sub-Saharan African countries including Ethiopia. In these counties, Schistosoma mansoni significant public health problem due to risk of reinfection recurrent disease despite implementing several rounds preventive chemotherapy. This systematic review meta-analysis aimed at assessing...

BACKGROUND The World Bank Loan Project (WBLP) for controlling schistosomiasis in China was implemented during 1992-2001. Its short-term impact has been assessed from non-spatial perspective, but its long-term impact remains unclear and a spatial evaluation has not previously been conducted. Here we compared the spatial distribution of schistosomiasis risk using national datasets in the lake and...

BACKGROUND Despite control efforts, human schistosomiasis remains prevalent throughout Africa, Asia, and South America. The global schistosomiasis burden has changed little since the new anthelmintic drug, praziquantel, promised widespread control. METHODOLOGY We evaluated large-scale schistosomiasis control attempts over the past century and across the globe by identifying factors that predi...

The current knowledge of immunological responses to schistosomiasis is insufficient for the development of vaccine and therapies. The role of T follicular helper (Tfh) cells in schistosome infections is not fully defined. The frequency of circulating Tfh cells and serum cytokine levels were analyzed in 11 patients with chronic schistosomiasis and 10 healthy controls (HC), who reside in an endem...