Chromosome higher order structure has been an enigma for over a century. The most important structural finding has been the presence of a chromosome scaffold composed of non-histone proteins; so-called scaffold proteins. However, the organization and function of the scaffold are still controversial. Here, we use three dimensional-structured illumination microscopy (3D-SIM) and focused ion beam/...

often assembled into their supramolecular complexes and targeted to specific regions of cells by multimodular scaffold proteins. The success of this organization and localization is critical for signaling efficiency and specificity. The catalytically inactive scaffold proteins that perform these tasks are traditionally viewed as passive molecules that " glue " signaling proteins together. Howev...

Incorporation of the herpes simplex virus 1 (HSV-1) portal vertex into the capsid requires interaction with a 12-amino-acid hydrophobic domain within capsid scaffold proteins. The goal of this work was to identify domains and residues in the UL6-encoded portal protein pUL6 critical to the interaction with scaffold proteins. We show that whereas the wild-type portal and scaffold proteins readily...

Abstract The transplantation of tissue-engineered scaffolds with stem cells is a promising therapeutic approach for bone defect repair. To improve the efficacy this approach, in study, novel biofunctional live bone-like graft was designed and constructed using fibrin scaffold loaded TG2 gene-modified ectomesenchymal (TG2-EMSCs) derived from nasal respiratory mucosa Autocalcification cell-free g...

Glutamate receptors on central nervous system (CNS) synapses are directly or indirectly associated with various scaffold proteins, most of which are localized at the postsynaptic density (PSD). Although the function of a number of these proteins is still unknown, it is now generally accepted that some regulate dendritic spine morphology and synapse function. Scaffold proteins bind and recruit p...

Scaffold proteins are abundant and essential components of the postsynaptic density (PSD). They play a major role in many synaptic functions including the trafficking, anchoring, and clustering of glutamate receptors and adhesion molecules. Moreover, they link postsynaptic receptors with their downstream signaling proteins and regulate the dynamics of cytoskeletal structures. By definition, PSD...