Recently it was shown by Nesterov (2011) that techniques form convex optimization can be used to successfully accelerate simple derivativefree randomized optimization methods. The appeal of those schemes lies in their low complexity, which is only Θ(n) per iteration—compared to Θ(n) for algorithms storing second-order information or covariance matrices. From a high-level point of view, those ac...

common and potentially deleterious rare variation in this pathway would be associated with severe asthma based on SARP cluster designation. Methods: To evaluate common variants (minor allele frequency or MAF .5%), 419 SARP non-Hispanic white participants with a cluster assignment were genotyped for 182 single nucleotide polymorphisms (SNPs) in Th2 pathway genes using whole-genome SNP data. Indi...

common and potentially deleterious rare variation in this pathway would be associated with severe asthma based on SARP cluster designation. Methods: To evaluate common variants (minor allele frequency or MAF .5%), 419 SARP non-Hispanic white participants with a cluster assignment were genotyped for 182 single nucleotide polymorphisms (SNPs) in Th2 pathway genes using whole-genome SNP data. Indi...

In this article, we propose a total generalized variation (TGV) [1] based model for removing multiplicative Gamma noise. To preserve edge more, we adopt a nonconvex regularizer to TGV regularization term. The model integrates the data-fitting energy proposed in [2] with a spatially adaptive regularization parameter (SARP) approach. The data-fidelity term enables to deal with heavy multiplicativ...

The Share-a-Ride Problem (SARP) aims at maximizing the profit of serving a set of passengers and parcels using a set of homogeneous vehicles. We propose an adaptive large neighborhood search (ALNS) heuristic to address the SARP. Furthermore, we study the problem of determining the time slack in a SARP schedule. Our proposed solution approach is tested on three sets of realistic instances. The p...

The static share-a-ride problem (SARP) consists of handling people and parcels in an integrated way through the same vehicle, which provides a shared trip between origin destination, response to requests received advance. When multiple providers compete on market (for instance, within city or region), horizontal cooperation can be efficient strategy consolidate all optimize total payoff. This s...

In this paper, the blocking probabilities of a hierarchical cellular system, with 36 macrocells and 27 microcells, under non-uniform traffic distribution have been simulated. Separated Autonomous Reuse Partitioning (SARP) and Hierarchical Autonomous Reuse Partitioning schemes (HARP) have been used to allocate channels to the users. It is found that at a GOS of 2% , HARP can accept more than dou...

12-O-Tetradecanoylphorbol.13-acetate (TPA)-mediated oxidative stress in HeLa cells and its inhibition were studied by fluorometric measurement of H2Oz and by 3H-postlabeling of the oxidized bases 8-hydroxyl-2'-deoxyguanosine (8-OHdG) and 5-hydroxymethyl-2'-deoxyuridine (HMdU). TPA treatment (10 fmol/cell) caused "~7-fold increase in H202 levels (0.1 nmol TPA/ml), and 5-10-fold increase in 8-OHd...

12-O-Tetradecanoylphorbol-13-acetate (TPA)-mediated oxidative stress in HeLa cells and its inhibition were studied by fluorometric measurement of H2O2 and by 3H-postlabeling of the oxidized bases 8-hydroxyl-2'-deoxyguanosine (8-OHdG) and 5-hydroxymethyl-2'-deoxyuridine (HMdU). TPA treatment (10 fmol/cell) caused approximately 7-fold increase in H2O2 levels (0.1 nmol TPA/ml), and 5-10-fold incre...