نتایج جستجو برای: salivary gland dysfunction
تعداد نتایج: 247197 فیلتر نتایج به سال:
Saliva plays an essential role in maintaining oral health. Alterations in salivary function lead to compromise of oral tissues and functions and have a large impact on a patient’s quality of life. Reductions in salivary flow most commonly manifest as symptoms of oral dryness. This subjective complaint of dry mouth is termed xerostomia, whereas objective alterations in salivary performance, quan...
Xerostomia frequently arises in patients with head and neck malignancies that are treated by radiation. However, the mechanisms responsible for the destruction of the salivary gland remain unknown. We previously established a xerostomia model of mice and identified the pathway through which nitric oxide (NO) affects the pathogenesis of radiation-induced salivary gland dysfunction. Although the ...
Introduction: Natural killer (NK) cells, of which CD56 is a specific marker, play an important role in host defense against tumors. Cancer stem cells, of which aldehyde dehydrogenase isoform 1 (ALDH1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. We aimed to evaluate the expression of ALDH1 and CD56 in common salivary g...
Sjögren’s syndrome (SS) is an autoimmune disease in which exocrine glands including the salivary gland are targeted and destroyed by the immune system (Voulgarelis and Tzioufas, 2010). SS and the side-effects of γ-radiation therapies for head and neck cancers cause salivary gland dysfunction, in particular hyposalivation (Atkinson et al., 2005; Fox, 1998; O'Sullivan and Higginson, 2010). Among ...
The purpose of the present study was to evaluate the validity of a scoring system based on excretion rate of salivary gland scintigraphy in patients with Sjögren's syndrome (SjS). Total scintigraphic scores were compared with the results of the Saxon test. One hundred and twenty-four subjects who were clinically diagnosed with SjS and 11 normal ones underwent salivary gland scintigraphy and the...
OBJECTIVE The objective of this study was to determine the effect of epithelial barrier disruption, caused by deficiency of the membrane-anchored serine protease, matriptase, on salivary gland function and the induction of autoimmunity in an animal model. METHODS Embryonic and acute ablation of matriptase expression in the salivary glands of mice was induced, leading to decreased epithelial b...
Inflammation of the salivary gland is a well-documented aspect of salivary gland dysfunction that occurs in Sjogren's syndrome (SS), an autoimmune disease, and in γ-radiation-induced injury during treatment of head and neck cancers. Extracellular nucleotides have gained recognition as key modulators of inflammation through activation of cell surface ionotropic and metabotropic receptors, althou...
introduction: natural killer (nk) cells, of which cd56 is a specific marker, play an important role in host defense against tumors. cancer stem cells, of which aldehyde dehydrogenase isoform 1 (aldh1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. we aimed to evaluate the expression of aldh1 and cd56 in common salivary g...
Sjögren’s syndrome, an autoimmune disease characterized by exocrine gland dysfunction leading to dry mouth and dry eye diseases, is typified by lymphoplasmacytic infiltrations and a progressive destruction of the salivary and lacrimal glands. Despite an ever-increasing focus on identifying the underlying etiology of Sjögren’s syndrome, the factors that initiate this autoimmune disease and the m...
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