While hyperpnea and reduction of the CO2 content of the blood are generally recognized findings of salicylate intoxication, little is known concerning the effect of therapeutic doses of salicylates. The prevailing impression (1) appears to be that such doses have no effect on the respiration. Investigations dealing with this question in experiments of a few hours duration showed small decreases...

Although new salicylates are now available for the treatment of ulcerative colitis, sulphasazaline still has an important therapeutic role. The role of salicylates in Crohn's disease is limited to the mild activity phase; further data are required to clarify its role in maintenance on remission. New steroids are a real alternative to traditional steroids in active ulcerative colitis and Crohn's...

The anti-inflammatory effects of salicylates, originally attributed to inhibition of cyclooxygenase activity, are currently known to involve additional mechanisms. In this study we investigated the possible modulation by salicylates of NFAT-mediated transcription in lymphocytic and monocytic cell lines. RNase protection assays showed that 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal) inhi...

OBJECTIVE To evaluate the effects on suicidal behaviour of legislation limiting the size of packs of paracetamol and salicylates sold over the counter. DESIGN Before and after study. SETTING UK population, with detailed monitoring of data from five liver units and seven general hospitals, between September 1996 and September 1999. SUBJECTS People who died by suicidal or accidental overdos...

The salicylates have been used in the symptomatic treatment of rheumatic disorders for over 50 years. They are capable of producing a striking change in the clinical picture of acute rheumatic fever and possess a smaller, but still definite, effect in rheumatoid arthritis. Their value as suppressive drugs appears to be concerned with alleviating the symptoms produced by the inflammatory process...