We intended to develop a desired ointment base suitable for treatment of bedsores including the proliferation of granulation and epidermis. The main bedsore bacteria detected in our hospital were S. aureus in gram-positive coccus and P. aeruginosa in gram-negative bacillus. As the macrogol ointment (MO) was found to have bactericidal effects on these bacteria, MO was adopted as the base for the...

The wound healing activity of ethanol extract of Terminalia bellirica Roxb. fruit was evaluated on excision and incision wound model, in albino rats, in the form of an ointment with two concentrations (2 and 4% w/w ointment) of fruit extract in simple ointment base. Both concentrations of the ethanol extract showed significant response in both the wound types tested when compared with the contr...

Spider web is being used in India and other countries to promote wound healing. Its ointment at 2.5 and 5% w/w concentrations was tested for wound healing activity in excision and incision wound models in rats. A significant reduction in the area of excision wound was observed for both the treatments when compared to normal healing and control ointment treatments. The period of epithelization f...

Adult and pediatric patients (n = 347) with atopic dermatitis enrolled in three multicenter, randomized, 6-week studies who had previously used steroids were analyzed to examine the null hypothesis that improvement in atopic dermatitis initiated after prior treatment with steroids eliminates any subsequent treatment differences between tacrolimus ointment and pimecrolimus cream. Of these patien...

BACKGROUND To compare the safety and efficacy of loteprednol etabonate ophthalmic ointment 0.5% (LE ointment), a new topical ointment formulation, with vehicle for the treatment of inflammation and pain following cataract surgery. METHODS Two randomized, multicenter, double-masked, parallel-group, vehicle-controlled studies were conducted. Patients aged ≥18 years with a combined postoperative...

A 60% (W/W) simple ointment of Udumbar (Ficus glomeruta) was prepared. The cases of cervical erosion were selected from S.S. Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi. The ointment was applied in the form of tampon following electric cauterization and compared the results with the triples sulpha ointment. It showed 95% cure rate as against 85% of Triple sulpha ...

BACKGROUND Oronine H(®) ointment, which contains chlorhexidine gluconate as its active component, is a well known disinfectant, and has been widely used for treatment of acne in Japan. In this study, we investigated the inhibitory effect of this ointment on the formation of comedones induced by application of 50% oleic acid on the orifices of the external auditory canals of rabbits. METHODS T...

Recently, numerous compounds have been studied in order to develop antibacterial agents, which can prevent colonized wounds from infection, and assist the wound healing. For this purpose, novel silver chloride nanoparticles stabilized with chitosan oligomer (CHI-AgCl NPs) were synthesized to investigate the influence of antibacterial chitosan oligomer (CHI) exerted by the silver chloride nanopa...

Comparative antimicrobial activity of four ointments, i. e. stellanin-PEG, levomecole, dioxydin 5% ointment and betadin was studied with the use of collection microbial strains and the most frequent pathogens of pyoinflammary processes in surgical patients. Clinical strains of gram positive and gram negative organisms were used as the test cultures. Stellanin-PEG 3% ointment showed high antimic...

In vitro release characteristics of prednisolone (PD) and its ƒÀand ƒÁ-cyclodextrin (ƒÀand ƒÁCyD) complexes were investigated by using an ointment release simulator with artificial doublelayer membranes. The release of PD from hydrophilic ointment was significantly improved by ƒÀand ƒÁ-CyD complexations. Permeation and uptake studies indicated that the enhanced release of PD from the ointment m...