نتایج جستجو برای: s144

تعداد نتایج: 28  

2006
Stéphanie Migrenne Céline Cruciani-Guglielmacci Ling Kang Ruokun Wang Claude Rouch Anne-Laure Lefèvre Alain Ktorza Vanessa H. Routh Barry E. Levin Christophe Magnan

It is now clearly demonstrated that fatty acids (FAs) may modulate neural control of energy homeostasis and specifically affect both insulin secretion and action. Indeed, pancreatic -cells receive rich neural innervation and FAs induce important changes in autonomic nervous activity. We previously reported that chronic infusion of lipids decreased sympathetic nervous system activity and led to ...

2016
Nilofer Husain Nikhil Kumar Tulsian Wang Loo Chien Sushant Suresh Ganesh Srinivasan Anand J. Sivaraman

Aminoglycosides are broad-spectrum antibiotics that bind to the 30S ribosomal subunit (30S) of bacteria and disrupt protein translation. NpmA, a structurally well-characterized methyltransferase identified in an E. coli clinical isolate, catalyzes methylation of 30S at A1408 of the 16S rRNA and confers aminoglycoside resistance. Using sucrose cushion centrifugation and isothermal titration calo...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Mei Leng Doug W Chan Hao Luo Cihui Zhu Jun Qin Yi Wang

Spindle assembly checkpoint (SAC) ensures bipolar attachment of chromosomes to the mitotic spindle and is essential for faithful chromosome segregation, thereby preventing chromosome instability (CIN). Genetic evidence suggests a causal link between compromised SAC, CIN, and cancer. Bloom syndrome (BS) is a genetic disorder that predisposes affected individuals to cancer. BS cells exhibit eleva...

Journal: :Journal of the American Society of Nephrology : JASN 2012
Kukiat Tudpor Sergio Laínez Arjan J Kwakernaak Nadezda V Kovalevskaya Sjoerd Verkaart Siebe van Genesen Annemiete van der Kemp Gerjan Navis René J M Bindels Joost G J Hoenderop

Urinary proteins that leak through the abnormal glomerulus in nephrotic syndrome may affect tubular transport by interacting with membrane transporters on the luminal side of tubular epithelial cells. Patients with nephrotic syndrome can develop nephrocalcinosis, which animal models suggest may develop from impaired transcellular Ca(2+) reabsorption via TRPV5 in the distal convoluted tubule (DC...

2011
Debin Mao Shouqin Lü Ning Li Yan Zhang Mian Long

β₂ integrin of lymphocyte function-associated antigen-1 (LFA-1) or macrophage-1 antigen (Mac-1) binds to their common ligand of intercellular adhesion molecule-1 (ICAM-1) and mediates leukocyte-endothelial cell (EC) adhesions in inflammation cascade. Although the two integrins are known to have distinct functions, the corresponding micro-structural bases remain unclear. Here (steered-)molecular...

Journal: :Journal of virology 2006
Olivier Lada Yves Benhamou Thierry Poynard Vincent Thibault

In chronic hepatitis B (CHB), the persistence of hepatitis B surface antigen (HBs Ag) is sometimes associated with antibodies (Ab) to HBs (anti-HBs). To assess the hypothesis of the selection of HBs Ag immune escape variants in CHB patients, the variability of the HBV S gene was determined for patients persistently carrying both HBs Ag and anti-HBs antibodies and patients solely positive for HB...

2005
Susan Karcz

Preface —O. M. Galal, C. G. Neumann, and J. Hulett ................................................................................ S127 Introduction —E. Pollitt .............................................................................................................................. S131 Children’s healthful eating: From research to practice —A. Worsley .......................................

Journal: :Physiological reviews 1999
B D Schultz A K Singh D C Devor R J Bridges

Pharmacology of CFTR Chloride Channel Activity. Physiol. Rev. 79, Suppl.: S109-S144, 1999. - The pharmacology of cystic fibrosis transmembrane conductance regulator (CFTR) is at an early stage of development. Here we attempt to review the status of those compounds that modulate the Cl- channel activity of CFTR. Three classes of compounds, the sulfonylureas, the disulfonic stilbenes, and the ary...

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