The capacity of the surface glycoproteins of enveloped viruses to mediate virus/cell binding and membrane fusion requires a proper thiol/disulfide balance. Chemical manipulation of their redox state using reducing agents or free sulfhydryl reagents affects virus/cell interaction. Conversely, natural thiol/disulfide rearrangements often occur during the cell interaction to trigger fusogenicity, ...

An excessive, non-resolving inflammatory response underlies severe COVID-19 that may have fatal outcomes. Therefore, the investigation of endogenous pathways leading to resolution inflammation is interest uncover strategies for mitigating in people with SARS-CoV-2 infection. This becomes particularly urgent individuals preexisting pathologies characterized by chronic respiratory and prone bacte...

Porcine transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PDEV) can cause severe diarrhea in pigs. Development of effective vaccines against TGEV and PEDV is one of important prevention measures. The spike (S) protein is the surface glycoprotein of TGEV and PEDV, which can induce specific neutralization antibodies and is a candidate antigen for vaccination attempts...

(1) For all real numbers s1, s3, s4, l such that s1 ≤ s3 and s1 ≤ s4 and 0 ≤ l and l ≤ 1 holds s1 ≤ (1− l) · s3 + l · s4. (2) For all real numbers s1, s3, s4, l such that s3 ≤ s1 and s4 ≤ s1 and 0 ≤ l and l ≤ 1 holds (1− l) · s3 + l · s4 ≤ s1. (3) If n > 0, then mn mod m = 0. (4) If j > 0 and i mod j = 0, then i÷ j = j . (5) If n > 0, then in÷ i = in i . (6) If 0 < n and 1 < r, then 1 < rn. (7)...

A new method that allows rapid phenotyping of genetic Lp(a) glycoprotein types in large numbers of samples is described. The method is based on sodium dodecyl sulfate gel electrophoresis of reduced serum or plasma in horizontal slab gels followed by immunoblotting with polyclonal anti-Lp(a) lipoprotein or monoclonal anti-Lp(a) glycoprotein antibodies. Phenotyping of 194 unrelated, healthy subje...

Leishmaniasis is a major infectious disease of considerable public health in more than 86 countries around the world. Several approaches toward vaccine development against this disease have been taken. Glycoprotein (gp63) is conserved among diverse species of Leishmania and has induced immunological responses in murine models. Therefore, this glycoprotein has been considered as a second generat...

The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes pathological pulmonary symptoms. Most efforts to develop vaccines and drugs against this virus target the spike glycoprotein, particularly its S1 subunit, which is recognised by angiotensin-converting enzyme 2. Here we use in-house developed tool CaverDock perform virtual screening glycoprotein using a cryogenic electro...

s of the 2011 Meeting of the Peripheral Nerve Society. June25–29, 2011. Potomac, Maryland, USA. J Peripher Nerv Syst2011;16(Suppl 3):S1–174.[35] Dalakas MC, Rakocevic G, Salajegheh M, et al. Placebo-controlledtrial of rituximab in IgM anti-myelin-associated glycoproteinantibody demyelinating neuropathy. Annals of neurology 2009;65(3):286–93. tional workshop: Outcome meas...