UNLABELLED PREMISE OF THE STUDY Here we propose a staining protocol using toluidine blue (TBO) and ruthenium red to reliably identify secondary compounds in the leaves of some species of Myrtaceae. • METHODS AND RESULTS Leaves of 10 species representing 10 different genera of Myrtaceae were processed and stained using five different combinations of ruthenium red and TBO. Optimal staining c...

s Ruthenium Supramolecular chemistry Cage compounds ridyl)p

Ruthenium is a fission product that can be released from the fuel in case of a severe nuclear accident. In this work the impact of the atmosphere composition, including air radiolysis products, on the transport of ruthenium through a primary circuit was examined. Experiments were performed at temperatures 1300, 1500 and 1700 K in a slightly humid air. In the experiments significant effect of ni...

Upon the screening of 16 antiproliferative compounds against Toxoplasma gondii and Neospora caninum, two hydrolytically stable ruthenium complexes (compounds 16 and 18) exhibited 50% inhibitory concentrations of 18.7 and 41.1 nM (T. gondii) and 6.7 and 11.3 nM (N. caninum). To achieve parasiticidal activity with compound 16, long-term treatment (22 to 27 days at 80 to 160 nM) was required. Tran...

BACKGROUND From the thousands of years, metal compounds have been used in medicine for treatment of various diseases including various types of cancers. Ruthenium was seen as a promising metal due to its similar kinetics to platinum and its lower toxicity. Therefore, we aimed to evaluate the newer mononuclear ruthenium (II) compounds for antinociceptive and antitumor activities. MATERIALS AND...

The present study was conducted to evaluate in vivo anticancer activity of two novel mononuclear ruthenium(II) compounds, namely Ru(1,10-phenanthroline)2(2-nitro phenyl thiosemicarbazone)Cl2 (Compound R1) and Ru (1,10-phenanthroline)2(2-hydroxy phenyl thiosemicarbazone)Cl2 (Compound R2) against Ehrlich ascites carcinoma (EAC) mice and in vitro cytotoxic activity against IEC-6 (small intestine) ...

It is now well-known that (2)H solid-state NMR techniques can bring a better understanding of the interaction of deuterium with metal atoms in organometallic mononuclear complexes, clusters or nanoparticles. In that context, we have recently obtained experimental quadrupolar coupling constants and asymmetry parameters characteristic of deuterium atoms involved in various bonding situations in r...

This review addresses the search for activity enhancement of leishmanicidal organic compounds through their coordination chemistry with ruthenium. In an introduction to leishmaniasis, its clinical manifestations, geographical distribution, available forms treatment, and challenges disease management are presented. Ruthenium complexes, owing physico-chemical biological properties, introduced as ...

One of the main challenges in cancer chemotherapy is to develop drugs that selectively target cancer cells in order to reduce general toxicity and consequently side effects. One such targeting method involves using large carrier compounds that release a drug once inside a cancer cell, since large compounds selectively accumulate in cancer tissue due to the “enhanced permeability and retention e...