Hemolytic uremic syndrome (HUS) is a life-threatening infectious disease in childhood for which there is no confirmed therapeutic strategy. Endothelial inflammation leading to microthrombosis formation via complement activation is the main pathology of HUS. Thrombomodulin is an endothelial membrane protein that has anticoagulation and antiinflammatory effects, including the suppression of compl...

Reverse time migration (RTM) is a commonly employed imaging technique in seismic applications (e.g., to image reservoirs of oil). Its standard implementation cannot account for multiple scattering/reverberation. For this reason it has not yet found application in nondestructive evaluation (NDE). This paper applies RTM imaging to NDE applications in bounded samples, where reverberation is always...

Reverse time migration (RTM) is theoretically more accurate than traditional migration methods because it computes numerical solutions to the complete wave equation. But RTM is computationally expensive especially for 3D data. To overcome this expense, Luo amd Schuster (2004) suggested a bottom-up reverse time datuming (RTD) method that promised to significantly decrease the computational time ...

Background. Cohort studies have reported that patients improve considerably after individualised homeopathic treatment. However, these results may be biased by regression to the mean (RTM). Objective. To evaluate whether the observed changes in previous cohort studies are due to RTM and to estimate RTM adjusted effects. Methods. SF-36 quality-of-life (QoL) data from a German cohort of 2827 chro...

BACKGROUND The interval from the R wave to the maximum amplitude of the T wave (RTm) contains the heart rate dependency of ventricular repolarization. METHODS AND RESULTS A computer algorithm was developed to quantify the RTm and preceding RR intervals for each of more than 50,000 beats on 24-hour ambulatory electrocardiographic (Holter) recordings to evaluate the dynamic relation between rep...

Individual differences in preschoolers' understanding that human action is caused by internal mental states, or representational theory of mind (RTM), are heritable, as are developmental disorders such as autism in which RTM is particularly impaired. We investigated whether polymorphisms of genes affecting dopamine (DA) utilization and metabolism constitute part of the molecular basis of this h...

BACKGROUND Disseminated intravascular coagulation (DIC) after liver transplantation (LT) is a difficult complication. We report a case of disseminated intravascular coagulation after deceased donor liver transplantation (DDLT) treated with recombinant thrombomodulin (rTM). CASE PRESENTATION A 30-year-old woman underwent right tri-segment split graft DDLT for acute liver failure. She developed...

In physical geodesy, the residual terrain modelling (RTM) technique is frequently used for highfrequency gravity forward modelling. In the RTM technique, a detailed elevation model is high-pass filtered in the topography domain, which is not equivalent to filtering in the gravity domain. This in-equivalence, denoted as spectral filter problem of the RTM technique, gives rise to two imperfection...

In this paper, first the limitations of the ray-based method and the one-way wave-field extrapolation migration (WEM) in imaging steeply dipping structures are discussed by some examples. Then a new method of the reverse time migration (RTM), used in imaging such complex structures is presented. The proposed method uses a new wave-field extrapolator called the Leapfrog-Rapid Expansion Method (L...

BACKGROUND Medical researchers often use longitudinal observational studies to examine how risk factors predict change in health over time. Selective attrition and inappropriate modeling of regression toward the mean (RTM) are two potential sources of bias in such studies. METHOD The current study used Monte Carlo simulations to examine bias related to selective attrition and inappropriate mo...