نتایج جستجو برای: rs9939609 polymorphism

تعداد نتایج: 107470  

2011
Harald Mangge Wilfried Renner Gunter Almer Daniel Weghuber Reinhard Möller Renate Horejsi

A common T/A polymorphism (rs9939609) in the fat mass and obesity associated (FTO) gene was found associated with early-onset and severe obesity in both adults and children. However, recent observations failed to find associations of FTO with obesity. To investigate the genetic background of early obesity, we analysed the single nucleotide polymorphism (SNP) rs9939609 of FTO in 371 styrian adol...

2016
Carmen Duicu Cristina Oana Mărginean Septimiu Voidăzan Florin Tripon Claudia Bănescu

Obesity is a disorder with increasing frequency in children and adolescents, directly linked with various diseases. Variants in the FTO (fat mass and obesity-related) gene have been associated with body mass index and waist and hip circumferences in widespread populations.The aim of this case-control study was to assess if there is any association between FTO gene variants rs9939609, respective...

2014
Izabela Chojnicka Sylwia Fudalej Anna Walczak Krystyna Wasilewska Marcin Fudalej Piotr Stawiński Katarzyna Strawa Aleksandra Pawlak Marcin Wojnar Paweł Krajewski Rafał Płoski Martin Voracek

The A allele of rs9939609 in the FTO gene predisposes to increased body mass index (BMI) and obesity. Recently we showed an inverse association between the obesity related A allele of rs9939609 and alcohol dependence which was replicated by others. Since this finding raises a possibility that FTO may be associated with other psychiatric phenotypes, we aimed to examine association of rs9939609 w...

2017
Ji Hee Yu Inkyung Baik Hyun Joo Cho Ji A. Seo Sin Gon Kim Kyung Mook Choi Sei Hyun Baik Dong Seop Choi Chol Shin Nan Hee Kim

The fat mass and obesity-associated (FTO) rs9939609 polymorphism have been associated with the increased metabolic risk and mortality, irrespective of obesity. The mechanism underlying this association is not known. We aimed to evaluate whether the FTO rs9939609 risk variant is independently associated with metabolic risk factors and/or leukocyte telomere length (LTL). We further aimed to inves...

2013
Adeela Shahid Sobia Rana Shahid Saeed Muhammad Imran Nasir Afzal Saqib Mahmood

Numerous studies confirmed the association of FTO (fat mass and obesity associated gene) common variant, rs9939609, with obesity in European populations. However, studies in Asian populations revealed conflicting results. We examined the association of rs9939609 variant of FTO gene with obesity and obesity-related anthropometric and metabolic parameters in Pakistani population. Body weight, hei...

Journal: :Obesity facts 2012
Timo D Müller Brandon H Greene Laura Bellodi Maria C Cavallini Elena Cellini Daniela Di Bella Stefan Ehrlich Stefano Erzegovesi Xavier Estivill Fernando Fernández-Aranda Manfred Fichter Christian Fleischhaker Susann Scherag Monica Gratacòs Harald Grallert Beate Herpertz-Dahlmann Wolfgang Herzog Thomas Illig Ulrike Lehmkuhl Benedetta Nacmias Marta Ribasés Valdo Ricca Helmut Schäfer André Scherag Sandro Sorbi Heinz-Erich Wichmann Johannes Hebebrand Anke Hinney

OBJECTIVE The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). METHODS Association of rs993960...

Journal: :Cardiovascular Diabetology 2008
Salam A Al-Attar Rebecca L Pollex Matthew R Ban T Kue Young Peter Bjerregaard Sonia S Anand Salim Yusuf Bernard Zinman Stewart B Harris Anthony JG Hanley Philip W Connelly Murray W Huff Robert A Hegele

BACKGROUND The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples. METHODS The FTO rs9939609 SNP was genotyped in 2121 subjects from four different non...

2011
Galina Lurie Mia M. Gaudet Amanda B. Spurdle Michael E. Carney Lynne R. Wilkens Hannah P. Yang Noel S. Weiss Penelope M. Webb Pamela J. Thompson Keith Terada Veronica Wendy Setiawan Timothy R. Rebbeck Jennifer Prescott Irene Orlow Tracy O'Mara Sara H. Olson Steven A. Narod Rayna K. Matsuno Jolanta Lissowska Xiaolin Liang Douglas A. Levine Loic Le Marchand Laurence N. Kolonel Brian E. Henderson Montserrat Garcia-Closas Jennifer Anne Doherty Immaculata De Vivo Chu Chen Louise A. Brinton Mohammad R. Akbari Marc T. Goodman

Overweight and obesity are strongly associated with endometrial cancer. Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity. We examined the association of FTO rs9939609 and MC4R rs17782313 with endometrial cancer risk in a pooled analysis of nine case-control st...

2014
Yan Feng Fengliang Wang Hongqiu Pan Sangsang Qiu Jieqiong Lü Liang Wu Jianming Wang Cheng Lu

BACKGROUND Obesity is known to affect cell-mediated immune responses. Recent studies have revealed that genetic polymorphisms in the fat mass and obesity associated (FTO) gene are related to human obesity. We hypothesize that this gene may also play a role in the risk of immune-related infectious diseases such as tuberculosis. METHODS This case-control study included 1625 pulmonary tuberculos...

2010
Harvest F. Gu Alexandra Alvarsson Kerstin Brismar

The fat mass and obesity associated (FTO) gene has an important genetic effect on body mass index (BMI) and risk of obesity, and obesity contributes to the progression of renal diseases, including diabetic nephropathy. We thus conducted a genetic association study to evaluate whether the FTO gene confers the risk susceptibility to the development of diabetic nephropathy. Genotyping experiments ...

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