نتایج جستجو برای: rs7517847

تعداد نتایج: 20  

2013
Di Hu Guohua Hu Jing Zhu Yang Shen Houyong Kang Suling Hong

OBJECTIVE Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was...

2013
María Carmen Cénit Ana Márquez Miguel Cordero-Coma Marina Begoña Gorroño-Echebarría Alejandro Fonollosa Alfredo Adán Agustín Martínez-Berriotxoa David Díaz Valle Esperanza Pato Ricardo Blanco Joaquín Cañal Manuel Díaz-Llopis José Luis García Serrano Enrique de Ramón María José del Rio José Manuel Martín-Villa Blanca Molins Norberto Ortego-Centeno Javier Martín

OBJECTIVE STAT4 and IL23R loci represent common susceptibility genetic factors in autoimmunity. We decided to investigate for the first time the possible role of different STAT4/IL23R autoimmune disease-associated polymorphisms on the susceptibility to develop non-anterior uveitis and its main clinical phenotypes. METHODS Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs8...

2010
Hongyan Zhou Zhengxuan Jiang Peizeng Yang Shengping Hou Fuzhen Li Qinmeng Shu Yuanyuan Chen Feilan Chen

PURPOSE The aim of the study was to investigate the association of polymorphisms of the interleukin-23 receptor (IL23R) gene with Fuchs' syndrome in a Chinese Han population. METHODS Three single-nucleotide polymorphisms (SNPs), rs7517847, rs11209032 and rs17375018 of IL23R were genotyped in 138 Chinese Han patients with Fuchs' syndrome and 407 healthy controls by using the polymerase chain r...

2013
Hongtao Dong Qiuming Li Ying Zhang Wei Tan Zhengxuan Jiang

PURPOSE The interleukin-23 receptor (IL-23R) has been shown to be associated with ankylosing spondylitis (AS) in many different populations. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. METHODS Three single-nucleotide polymorphisms (SNP), rs7517847, rs11209032, and rs17375018, were genotyped in 291 AS patient...

2017
Sarah Fischer Erzsébet Kövesdi Lili Magyari Veronika Csöngei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós

AIM To investigate the association of seven single nucleotide polymorphisms (SNPs) of the IL23R gene with the clinical picture of ulcerative colitis (UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, ...

Journal: :Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2012
Zdenka Navratilova Jiri Gallo Frantisek Mrazek Martin Petrek

BACKGROUND AND AIMS Prosthetic Joint Infection (PJI) is a serious complication of Total Joint Arthroplasty (TJA). The Th-17 immune response characterised by IL (interleukin)-17A, IL-17F, IL-23, chemotactic cytokines and their receptors, plays a prominent role in the immune response to invading bacteria. In addition, high expression of IL-17A has been reported in PJI. The aim of this study was t...

2010
Josef Wagner Winnie H. Sim Justine A. Ellis Eng K. Ong Anthony G. Catto-Smith Donald J. S. Cameron Ruth F. Bishop Carl D. Kirkwood

Genetic susceptibility is an important contributor to the pathogenesis of Crohn's disease (CD). We investigated multiple CD susceptibility genes in an Australian paediatric onset CD cohort. Newly diagnosed paediatric onset CD patients (n = 72) and controls (n = 98) were genotyped for 34 single nucleotide polymorphisms (SNPs) in 18 genetic loci. Gene-gene interaction analysis, gene-disease pheno...

2016
J Krsteski S Jurgec M Pakiž I But U Potočnik

Uterine leiomyomas (ULM) are a common cause of solid pelvic tumors in women. Their etiopathogenesis remains unclear. Interleukins (ILs) and their receptors can influence tumor biology of ULM. The aim of this study was to evaluate single nucleotide polymorphisms (SNPs) exhibited in the genes IL4 (rs2070874), IL4R (rs1801275), IL12RB1 (rs11575934), IL12B (rs6887695), IL13 (rs20541) and IL23R (rs7...

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