The individual response to diet may be influenced by gene polymorphisms. This study hypothesized that ADRB2 (Gln27Glu, rs1042714 and Arg16Gly, rs1042713), ADRB3 (Trp64Arg, rs4994) and GHRL (Leu72Met, rs696217) polymorphisms moderate weight loss. The study was a seven weeks dietary weight loss intervention with Brazilian adult obese women (n = 109). The body mass index (BMI) was calculated and p...

BACKGROUND The association between genetic polymorphisms of ADRβ2, IL-4, and ADAM3 and asthma remains undetermined. Furthermore, it is not clear as to whether these three gene polymorphisms combined produce a correlative increase in asthmatic risk. METHODS A total of 476 asthmatic patients and 115 healthy volunteers were enrolled. Single nucleotide polymorphisms (SNPs) of the C-589T IL-4 prom...

Background. The study of the effect drugs at molecular genetic level in recurrent course bronchial obstruction (RBО) children improved understanding pathogenesis disease and made it possible to better characterize reliability use therapy. aim was assess clinical significance polymorphism Arg16Gly loci ADRB2 gene with a therapeutic response β2-agonists RBО Uzbek ethnicity. Materials methods. Tes...

The non-synonymous mutations arg16gly (rs1042713) and gln27glu (rs1042714) in the adrenergic β-2 receptor gene (ADRB2) have been associated with cognitive function and brain white matter integrity. The current study aimed to replicate these findings and expand them to a broader range of cognitive and brain phenotypes. The sample used is a community-dwelling group of older people, the Lothian Bi...

Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in GAD, however direct evidence for genetic susceptibility is missing. This study evaluated the associations of gene variants in adrenergic receptors (ADRs) with GAD, with the involvement of stressful events. Data were ob...

BACKGROUND The association between β2-adrenergic receptor (ADRB2) -16Arg/Gly polymorphism (rs1042713) and chronic obstructive pulmonary disease (COPD) risk has been investigated in many published studies. However, the results were inconclusive. A meta-analysis was performed to make a more precise estimation of the relationship. METHODS The PubMed, EMBASE, ISI web of science, the Cochrane Data...

Introduction The A allele of rs1042713 (Arg16 amino acid) in the ? 2 -adrenoreceptor is associated with poor response to long-acting -agonist (LABA) young people asthma. Our aim was assess whether prescribing second-line controller LABA or a leukotriene receptor antagonist according Arg16Gly genotype would result improvements Pediatric Asthma-Related Quality Life Questionnaire (PAQLQ). Methods ...