Objective(s): Intracerebroventricular injection of orexin-A (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. However the locations of central sites that may mediate these effects have not been totally demonstrated. This study was performed to investigate the role of rostral ventromedial medulla (RVM) orexin receptor 1 in stress-induced analgesia (SIA). Materials and...

Objective(s): There are many reports about the role of rostral ventromedial medulla (RVM) in modulating stress-induced analgesia (SIA). In the previous study we demonstrated that temporal inactivation of RVM by lidocaine potentiated stress-induced analgesia. In this study, we investigated the effect of permanent lesion of the RVM on SIA by using formalin test as a model of acute inflammatory pa...

objective: it is well known that intracerebroventricular (icv) and supraspinal injections of orexin-a elicit analgesia, but the mechanism(s) of action remains unidentified. this study aims to characterize the effect of orexin-a on rostral ventromedial medulla (rvm) neurons which are involved in the descending nociception modulating pathway. materials and methods: in this experimental study, we ...

the rostral ventromedial medulla (rvm) acts a key role in the descending inhibitory pain modulation. neuropeptide orexin-a (orxa) is confined to thousands of neurons in the lateral hypothalamus (lh). while rvm gets the orexinergic projections, the orexin receptors are also expressed in this structure. the aim of this study was to specify the cellular effects of orxa on rvm neurons in vitro by u...