BACKGROUND Valvular endothelial cells and circulating endothelial progenitor cells (EPCs) can undergo apparent phenotypic change from endothelial to mesenchymal cell type. Here we investigated whether EPCs can promote extracellular matrix formation in tissue engineering scaffolds in response to transforming growth factor (TGF)-beta1. Method and Results- Characterized ovine peripheral blood EPCs...

Three-dimensional (3D) engineered tissue constructs are a novel and promising approach to tissue repair and regeneration. 3D tissue constructs have the ability to restore form and function to damaged soft tissue unlike previous methods, such as plastic surgery, which are able to restore only form, leaving the function of the soft tissue often compromised. In this study, we seeded murine myoblas...

A method was developed for the large-scale production of Marek's disease herpesvirus A antigen in duck embryo fibroblast roller bottle cultures in quantities sufficient to permit its purification and characterization. Maximum yield was obtained in serum-free culture medium harvested daily. The Marek's disease herpesvirus A antigen was stable at pH 2.0 and was a glycoprotein based on its sensiti...

Rat embryos, dissected from the uterus at 11 1/2 days' gestation, have been used to study the regenerative powers of the embryonic limb. One forelimb-bud of each embryo was amputated, via an incision in the membranes. Embryos were subsequently grown in roller-bottle cultures for 44 h, then examined histologically. Twenty-nine out of 32 healthy embryos had formed limb-bud regenerates, 14 of whic...

We are studying a hydraulic system design and vehicle dynamic modeling for a development of tire roller system, because those are very important in analysis of tire roller. Generally, tire roller is one of the useful machines in a road construction field and it technically applied for many other construction fields. Also, we conceptualize of new hydraulic and traction system, and define about t...

This paper presents a complete dynamic analysis of roller and vane of a rotary compressor widely used for air-conditioners. An approach and a set of equations are developed estimating the type of motion at vane tip and roller interface and calculating the frictional force in accordance with the motion type. The forces on roller caused by relative motion between roller and cylinder wall are anal...

Roller skis are used by cross-country skiers, biathletes and ski-orienteers for their snow-free training and in roller ski competitions. Additionally, much of the current sports research into the physiology and biomechanics of crosscountry skiing is conducted indoors on treadmills using roller skis. For elite athletes, the differences in performance are quite small, thus emphasising the importa...

The aim of this project is to develop methods for scaling up roller compaction process from lab scale to pilot scale, to determine the effect of processing parameters of roller compactors at both lab scale (instrumented roller compactor at University of Birmingham, micro-pactor at Pfizer) and pilot scale (mini-pactor from Gerteis) on the attributes of dry-granulated formulations, including the ...