The intercellular communication between osteoblasts and osteoclasts is crucial to bone homeostasis. Since Rodan and Martin proposed the control of osteoclasts by osteoblasts in the 1980s, many factors have been isolated from osteoblasts and shown to regulate the differentiation and function of osteoclasts. However, the mechanism by which osteoblasts regulate osteoclasts during bone remodelling ...

The ICONS (Intelligent CONtent management System) project objectives and contribution to the current state of the knowledge management field is presented. The project represents an ongoing international research effort funded by the European IST research programme. An important aspect of the project is the fact that its inception and the technological platform are based on the industrial softwa...

The theme of this article is the importance – and the many causes – of lowlevel equilibrium “traps.” Rosenstein-Rodan pointed out that spillovers may cause the return to an activity to increase with the number of others who undertake that activity. If spillovers are strong enough, both lowand high-level equilibria are possible, with no tendency of market forces to lead from the worse to the bet...

The ICONS (Intelligent CONtent management System) project objectives and contribution to the current state of the knowledge management field is presented. The project represents an ongoing international research effort funded by the European IST research programme. An important aspect of the project is the fact that its inception and the technological platform are based on the industrial softwa...

66. Fuentealba LC, Eivers E, Ikeda A. Hurtado C, Kuroda H, Pera EM, De Robertis E M 2007 Integrating patterning signals: Wnti GSK3 regulates the duration of the BMP/Smadl signal. Cell 13 1 : 980-993. 67. Sapkota G, Alarcon C, Spagnoli FM, Brivanlou AH, Massague J 2007 Balancing BMP signaling through integrated inputs into the Smadl linker. Mol Cell 25:441454. 68. Nakayama K, Tamura Y, Suzawa M,...

We appreciate the generous support of the National Science Foundation (IOC Award #0323176), the Stanford Technology Ventures Program, and the MIT Sloan School of Management. We also thank multiple individuals for their helpful comments, including Phil Anderson, Steve Barley, Diane Burton, Tim Carroll, Rebecca Henderson, Pankaj Ghemawat, Clark Gilbert, Riitta Katila, Bruce Kogut, Dan Levinthal, ...

Workflow management systems (WFMSs) need to adapt dynamic process modifications. In current WFMSs the scope of dynamic modifications is mainly focused on control flow, while other dynamic aspects are neglected. In this paper an approach to adapt dynamic modification in workflow participant assignment (WPA) is presented. The approach extends the meaning of WPA that is proposed by the Workflow Ma...

Workflow management systems (WFMSs) need to adapt dynamic process modifications. In current WFMSs the scope of dynamic modifications is mainly focused on control flow, while other dynamic aspects are neglected. In this paper an approach to adapt dynamic modification in workflow participant assignment (WPA) is presented. The approach extends the meaning of WPA that is proposed by the Workflow Ma...