Large Eddy Simulation (LES) is used to study natural circulation flow in a sealed rod bundle with Rayleigh number (based on height) of approximately 1011 and fluid Prandtl 0.74. Natural convection boundary layer development observed both the heating rods cooling containment surfaces. The layers key heat transfer characteristics system. As descends surface, gradually develops transitions from la...

Talin is a key protein involved in linking integrins to the actin cytoskeleton. The long flexible talin rod domain contains a number of binding sites for vinculin, a cytoskeletal protein important in stabilizing integrin-mediated cell-matrix junctions. Here we report the solution structure of a talin rod polypeptide (residues 1843-1973) which contains a single vinculin binding site (VBS; residu...

Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. It exists in both globular and extended conformations, and an intramolecular interaction between the N-terminal F3 FERM subdomain and the C-terminal part of the talin rod contributes to an autoinhibited form of the molecule. Here, we report the solut...

The talin rod contains approximately 11 vinculin binding sites (VBSs), each defined by hydrophobic residues in a series of amphipathic helices that are normally buried within the helical bundles that make up the rod. Consistent with this, talin failed to compete for binding of the vinculin Vd1 domain to an immobilized talin polypeptide containing a constitutively active VBS. However, talin did ...

The flow channel of the fluids in the nuclear reactor core and the heat exchanger is relatively small. In order to understand the two-phase flow phenomena in the narrow channel, many interesting studies have been carried out, for example, mini capillaries (Wong, et al., 1995, Han & Shikazono, 2009), rectangular channels with small gap (Mishima, et al., 1993, Xu, et al., 1999, Hibiki & Mishima, ...

Comparative analysis of the tryptic peptides and terminal amino acid sequence was made on polyhedrins from two genetically different baculoviruses that are naturally pathogenic for the same insect host. Comparison of the tryptic peptides of the nucleopolyhedrosis bundle virus and nucleopolyhedrosis single-rod virus of Orgyia pseudotsugata by means of cation-exchange resins indicated that the pr...

A CFD model of VVER-440 fuel assembly heads was developed based on the technical documentation of a full-scale test facility built in the Kurchatov Institute, Moscow. Steady-state and transient calculations were performed to validate the model with a measurement set and investigate the effects of the spatial discretization, choosing of different turbulence models and use of different inlet boun...

The grid-to-rod fretting (GTRF) problem in pressurized water reactors is a flow-induced vibration phenomenon that results in wear and failure of the cladding material on fuel rods. Grid-to-rod fretting is responsible for over 70% of the fuel leaks in pressurized water reactors in the U.S. The GTRFinduced wear process involves turbulent flow, mechanical vibration, tribology, and time-varying irr...