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BACKGROUND Antimicrobials constitute the second most common cause of contact allergy to cosmetics. Methylisothiazolinone (MI), previously always used together with methylchloroisothiazolinone (MCI), has recently been approved in the EU for use on its own in cosmetics and also various industrial products. MCI has been classified as an extreme-strong and MI as a strong-moderate sensitizer. OBJE...
Compound allergy to an antihemorrhoidal ointment demonstrated by the repeated open application test.
The most commonly used topical pharmacologic agents for symptomatic management of hemorrhoids include vasoconstrictors, astringents, anesthetics, keratolytics, corticosteroids, and antipruritic agents. Some of these drugs have been involved in contact dermatitis [1-7]. A 57-year-old woman presented with a pruritic, sharply demarcated, erythematous rash on the anogenital area that spread within ...
Anne Marie Api Research Institute for Fragrance Materials, Inc. (RIFM), Woodcliff Lake, New Jersey, USA J.H.E. Arts TNO Quality of Life, Zeist, Netherlands Harmonization Project Document No. 5 4 David Basketter Unilever Safety and Environmental Assurance Centre, Sharnbrook, Bedford, United Kingdom Jonathan Chen Antimicrobials Division, Office of Pesticide Programs, Environmental Protection Agen...
Preservatives, essential in our daily life, can sensitize and elicit allergic contact dermatitis (ACD). Before introduction in the market their sensitizing risk is assessed based on in vivo studies. However, normal exposures to preservative-containing products in the real world can cause ACD. During recent decades we recall several ‘epidemic’ outbreaks of ACD from newly introduced preservatives...
The exploration of the compositional space halide perovskites is prohibitively costly using traditional experimental research strategies. Sun and colleagues demonstrated a physics-informed, machine-learning-guided, approach that overturns this limitation enabling rapid efficient maximization stability in mixed-cation perovskites. In perovskite photovoltaics, experimentalism king. Thousands grou...
The authors report a case of intraoperative reversal apixaban with andexanet alfa in patient supported venoarterial extracorporeal membrane oxygenation due to low- cardiac-output immediately after surgery for acute type A aortic dissection and massive transfusion administration procoagulants. In this patient, alfa's off-label use was not associated thrombotic complications despite being given d...
Using a sample of 227 million Υ (4S) → BB events collected with the BABAR detector at the PEP-II B Factory in 1999–2004, we study B → D0 K (892) decays where K → K0 S π and D0 → K π+, K π+ π0, K π+ π+ π (non-CP final states), K+K−, π+ π (CP+ eigenstates), K0 S π0, K0 S φ and K0 S ω (CP− eigenstates). The partial rate charge asymmetries ACP and the ratios RCP defined in the literature as the sum...
We present updated measurements of branching fractions and CP -violating asymmetries for neutral B meson decays to two-body final states of charged pions and kaons. The results are obtained from a data sample of about 60 million Υ (4S) → BB decays collected between 1999 and 2001 by the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. The sample contains 124 −15 ππ, 403± 24 Kπ, ...
A preliminary study of time dependence of BB oscillations using dilepton events is presented. The avor of the B meson is determined by the charge sign of the lepton. To separate signal leptons from cascade and fake leptons we have used a method which combines several discriminating variables in a neural network. The time evolution of the oscillations is studied by reconstructing the time di ere...
We present preliminary results of a search for B0 → K0K0 decays in the K0 S K0 S final state using a sample of approximately 23 million BB pairs collected by the BABAR detector at the PEP-II asymmetric B Factory at SLAC. We find no evidence for a signal and set an upper limit on the branching fraction of 7.3 × 10−6 at the 90% confidence level. Submitted to the 9 International Symposium on Heavy...
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