Background: Tissue engineering has been investigated as a potential method for healing traumatized tissues. Biomaterials are material devices or implants used to repair or replace native body tissues and organs. The present study was conducted to evaluate the effects of decontamination methods on biological/mechanical properties and degradation/adhesion test of the platelet‑-rich fibrin (PRF) m...

OBJECTIVES: Previous reports have revealed that several cytokines (including platelet-derived growth factor-BB, transforming growth factors-β1 and insulin-like growth factor-1) can enhance the rate of bone formation and synthesis of extracellular matrix in orthopaedics or periodontology. This study aimed to determine the concentration of cytokines within platelet-rich fibrin microstructures and...

Pseudoarthrosis, or nonunion, of the long bones is a challenging medical condition for orthopedic surgeons to treat. Therefore, healing enhancer materials are commonly used. The authors investigated whether platelet-rich fibrin accelerates long bone healing by comparing radiological and histological findings in a rat model of open femoral fracture. Platelet-rich fibrin is a current biomaterial ...

objective: ovarian and follicle transplantation may preserve fertility in young cancer survivors. in this study, we have transplanted preantral follicles using fibrin gel as a carrier and fibrin gel supplemented with platelet lysate (pl) as a rich source of angiogenic and growth factors. the purpose of this study was to evaluate the role of fibrin gel and pl in follicle transplantation. materia...

The development of novel regenerative material to reduce inflammation and enhance healing process is one the greatest task in clinical research. PRF ( platelet rich fibrin) an second generation concentrate which has gained popularity recent years due its unique process. Platelet Rich Fibrin completely autologous with extended growth factor release compared other concentrates. standard quality q...

Thrombus fragmentation during endovascular stroke treatment, such as mechanical thrombectomy, leads to downstream emboli, resulting in poor clinical outcomes. Clinical studies suggest that risk is dependent on clot composition. This current study presents the first experimental characterization of composition-dependent fracture properties blood clots, addition development a predictive model for...

Introduction: One of the most common complications following total laryngectomy is pharyngocutaneous fistula (PCF). Various methods have been proposed to treat this disorder in recent studies, including a range of simple and conservative treatments to more aggressive therapies, such as various surgical procedures. One of the most innovative and least developed methods is the use of plasma...

Conclusion The platelet-rich plasmas failed to demonstrate significant benefits that justify the daily use, and the use of platelet-rich fibrin is limited to some very specific applications in which satisfactory results were achieved. Only a new simple, inexpensive and efficient technique such as the leucocyteand platelet-rich fibrin will continue to develop in oral and maxillofacial surgery in...