1. Riboflavin deficiency at two levels of severity was produced in weanling rats by feeding deficient diets for 6 weeks and using neck collars to prevent coprophagy. The severity of deficiency was monitored by growth, liver flavin levels and the activation coefficient of erythrocyte glutathione oxidoreductase (NAD(P)H) (EC 1 . 6 .4 .2 ) . Control groups, receiving the same diet with ample added...

Riboflavin secretion by Hyoscyamus albus hairy roots under Fe deficiency was examined to determine where riboflavin is produced and whether production occurs via an enhancement of riboflavin biosynthesis or a stimulation of flavin mononucleotide (FMN) hydrolysis. Confocal fluorescent microscopy showed that riboflavin was mainly localized in the epidermis and cortex of the root tip and, at the c...

The effect of riboflavin deficiency on in vivo incorporation of [1-14C] leucine into proteins of liver has been studied on rats following protein depletion and subsequent repletion. The increase in the incorporation of [14C] amino acid into liver proteins follow ing protein depletion was less marked in riboflavin-deficient rats. But repletion with 40% protein demonstrated marked diminished prot...

1. Riboflavin deficiency at two levels of severity was produced in weanling rats by feeding deficient diets for 6 weeks and using neck collars to prevent coprophagy. The severity of deficiency was monitored by growth, liver flavin levels and the activation coefficient of erythrocyte glutathione oxidoreductase (NAD(P)H) (EC 1.6.4.2). Control groups, receiving the same diet with ample added ribof...

FASS, STEVEN, AND RICHARD S. RIVLIN. Regulation of riboflavinmetabolizing enzymes in ribuj?auin de_ficiency. Am, J. Physiol. 217(4) : 988-99 1. 1969.-The effects of riboflavin deficiency in rats on the hepatic activities of flavokinase, FAD pyrophosphorylase, and FMN phosphatase, three enzymes involved in riboflavin metabolism, have been measured and compared to the hepatic concentrations of FA...

The erythrocyte antioxidant enzyme levels of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of riboflavin-deficient and Trichinella spiralis-infected rats were investigated. The rats were deprived of riboflavin at the 8th week of the experiment. At that time, the erythrocyte glutathione reductase activity coefficient (EGR AC), as an indicator of riboflavin status, was ...

1. A study amongst schoolboys in villages around Hyderabad, India, showed that almost all the boys had riboflavin deficiency, 61% had pyridoxine deficiency, and 9.4% had thiamin deficiency as judged by enzymic tests. 2. The prevalence of angular stomatitis was 41.3% and that of glossitis was 18.2%. Biochemical deficiency of riboflavin and pyridoxine was marginally higher in children with angula...

An adolescent population ranging in age from 13 to 19 years and of a low socioeconomic status in New York City was surveyed for riboflavin deficiency. Deficiency was determined from estimation of erythrocyte glutathione reductase activity, an accurate reflector of riboflavin nutritional status. The overall prevalence of deficiency among those not on vitamin supplements was 26.6%. The prevalence...

By MONTAGUE LAisn AND CLARENCE P. ALFREY, Jn. T HE RAPID INDUCTION of experimental riboflavin deficiency in man resulted in the development of a severe anemia which was reversed by riboflavin administration.1’2 In addition to the anemia, the patients developed a deficiency syndrome characterized by sore throat, hyperemia and edema of the pharyngeal and oral mucous membranes, cheilosis, angular ...

After 21-day-old weanling rats were maintained on diets deficient in riboflavin the weights of their brains were 19.8% less than those of rats on control diets. In riboflavin deficiency, the myelin lipids, cerebrosides, and sphingomyelin, as well as phosphatidylethanolamine, a significant component of the myelin membrane, were considerably reduced in proportion. It is considered that riboflavin...