Talin is an integrin adaptor, which controls integrin activity in all hematopoietic cells. How intracellular signals promote talin binding to the integrin tail leading to integrin activation is still poorly understood, especially in leukocytes. In vitro studies identified an integrin activation complex whose formation is initiated by the interaction of active, guanosine triphosphate (GTP)-bound...

The Rap1-GTP interacting adapter protein (RIAM) is an important protein in Rap1-mediated integrin activation. By binding to both Rap1 GTPase and talin, RIAM recruits talin to the cell membrane, thus facilitating talin-dependent integrin activation. In this article, we studied the role of the RIAM Ras-association (RA) and pleckstrin-homology (PH) domains in the interaction with Rap1. We found th...

The present paper tries to assess different scenarios for solid waste management in Khorramabad industrial park. It uses a new hybrid method of fuzzy Rapid Impact Assessment Matrix, and proposes the Fuzzy theory, the ranking method of which is innovated so that the accuracy and flexibility of the RIAM method could be improved. Four scenarios are studied, namely open dumping, sanitary landfill, ...

The present paper tries to assess different scenarios for solid waste management in Khorramabad industrial park. It uses a new hybrid method of fuzzy Rapid Impact Assessment Matrix, and proposes the Fuzzy theory, the ranking method of which is innovated so that the accuracy and flexibility of the RIAM method could be improved. Four scenarios are studied, namely open dumping, sanitary landfill, ...

Adaptive immunity depends on lymphocyte adhesion that is mediated by the integrin lymphocyte functional antigen 1 (LFA-1). The small guanosine triphosphatase Rap1 regulates LFA-1 adhesiveness through one of its effectors, Rap1-interacting adapter molecule (RIAM). We show that RIAM was recruited to the lymphocyte plasma membrane (PM) through its Ras association (RA) and pleckstrin homology (PH) ...

a r t i c l e i n f o Keywords: Strategic environmental assessment (SEA) Rapid impact assessment matrix (RIAM) Analytic Hierarchy Process (AHP) Integrated environmental score (IES) Indicator weighting Urban planning Strategic environmental assessment (SEA) has become an increasingly important decision-support tool for providing information on the environmental implications of a policy, plan, or...

Background: Identifying the effects of industrial complexes on environmental components is essential in activities’ development planning. Objectives: The purpose this study was to evaluate impact Khorramabad parks using hybrid modeling. Methods: In study, a fuzzy expert system used parks. proposed model, inference (FIS) designed based Mamdani method and rapid assessment matrix (RIAM) model. Res...

Integrins are a/b heterodimeric transmembrane receptors that are expressed on all cells. They provide stable adhesion of cells to the extracellular matrix or to other cell counter receptors by forming complex adhesion sites, which serve as signaling platforms (outside-in signaling) that induce cell polarity, migration, survival, and proliferation. Because integrins reside in an inactive state, ...