Abstract Regulators conduct regulatory impact analyses (RIA) to evaluate whether actions fulfill the desired goals. Although there are different frameworks for conducting RIA, they only applicable regulations whose can be measured with structured data. Yet, a significant and increasing number of require firms comply by specifying communicating textual data consumers supervisors. Therefore, we d...

Sempre atenta aos principais debates da arte contempor�nea e � produ��o escrita dos artistas, a professora, cr�tica, curadora editora Gl�ria Ferreira trouxe contribui��es inestim�veis para renova��o te�rica expans�o das pesquisas em no Brasil. Transitando entre os campos educa��o, trajet�ria de sempre foi insepar�vel do seu engajamento pol�tico ? desde o combate ditadura militar at� voz ativa m...

Radioimmunoassay (RIA) employing iodinated ligands represents a popular measurement method for small molecules due to its excellent sensitivity and specificity. Yet performing RIAs of large numbers of tubes remains a tedious laboratory chore due to the need to individually handle tubes multiple times. We here present a method in which conventional 125I-labeled RIA ([125I] RIA) is adapted to a m...

Natural antibodies provide an early defense mechanism against pathogens, show a frequent self-reactivity, and are present throughout life. Two questions concern the physiological control of selfreactivity and the pathogenetic link to autoimmune disease. Here we propose a concept of conditional autoimmunity involving natural antibodies against the a chain of the high-affinity receptor for IgE (F...

Glucagon has a short plasma t(1/2) in vivo, with renal extraction playing a major role in its elimination. Glucagon is degraded by neutral endopeptidase (NEP) 24.11 in vitro, but the physiological relevance of NEP 24.11 in glucagon metabolism is unknown. Therefore, the influence of candoxatril, a selective NEP inhibitor, on plasma levels of endogenous and exogenous glucagon was examined in anes...

Crawling web applications is important for indexing, accessibility and security assessment. Crawling traditional web applications is an old problem, for which good and efficient solution are known. Crawling Rich Internet Applications (RIA) quickly and efficiently, however, is an open problem. Technologies such as AJAX and partial Document Object Model (DOM) updates only make the problem of craw...

This paper explores how the Resource Interaction Approach (RIA), namely 4Rs model and three settings of developing-producing-using, can be applied to complex policy analyses. We use global sustainability challenge antibiotic resistance as an example define agenda about these analytical tools frame analyze such problems systematically. find that offer benefits policymakers, including flexibility...