Technetium labelled, negatively charged, unilamellar liposomes were given by intravenous injection to patients with rheumatoid arthritis and the joints scanned 20-22 hours later. Positive scintigraphy was obtained in all six patients with active disease, and, with the exception of the small interphalangeal joints, all clinically involved joints could be visualised.

This research aimed to develop new tumor targeted theranostic agents taking advantage of the similarities in coordination chemistry between technetium and rhenium. A γ-emitting radioactive isotope of technetium is commonly used in diagnostic imaging, and there are two β- emitting radioactive isotopes of rhenium that have the potential to be of use in radiotherapy. Variants of the 6-hydrazinonic...

Coacervates have been widely studied as model compartments in protocell research. Complex coacervates composed of disordered proteins and RNA have also been shown to play an important role in cellular processes. Herein, we report on a microfluidic strategy for constructing monodisperse coacervate droplets encapsulated within uniform unilamellar liposomes. These structures represent a bottom-up ...

Cutaneous squamous cell carcinoma (SCC) is the second most common form of skin cancer. In cases, non-invasive SCC has a good prognosis and curable by surgical resection. Nevertheless, small percentage patients pose specific management problems due to technical difficulty maintaining function aesthetics because size or location tumor. An emerging therapeutic approach with high-dose brachytherapy...

SP94 (SFSIIHTPILPL), a novel peptide, has shown specific binding to hepatocellular carcinoma (HCC) cells. We aimed to investigate the capability of SP94 as a targeting probe for HCC imaging and therapy following labeling with technetium-99m ((99m)Tc) and rhenium-188 ((188)Re). HYNIC-SP94 was prepared by solid phase synthesis and then labeled with (99m)Tc. Cell competitive binding, internalizati...

The decay of (187)Re to (187)Os (with a half-life of 42 billion years) provides a unique isotopic fingerprint for tracing the evolution of crustal materials and mantle residues in the convecting mantle. Ancient subcontinental mantle lithosphere has uniquely low Re/Os and (187)Os/(188)Os ratios due to large-degree melt extraction, recording ancient melt-depletion events as old as 3.2 billion yea...