نتایج جستجو برای: rg108
تعداد نتایج: 41 فیلتر نتایج به سال:
Enhanced receptiveness at all synapses on a neuron that receive glutamatergic input is called cell-wide synaptic upscaling. We hypothesize that this type of synaptic plasticity may be critical for long-term memory storage within cortical circuits, a process that may also depend on epigenetic mechanisms, such as covalent chemical modification of DNA. We found that DNA cytosine demethylation medi...
درشبیه سازی به روش انتقال هسته ی سلول سوماتیکی، هسته ی انتقالی باید از حالت تمایز یافته به حالت جنینی باز برنامه-ریزی شود. آنالیز های مولکولی نشان می دهند که باز برنامه ریزی در هسته ی انتقالی ناکامل بوده و جنین های شبیه سازی شده مدیفیکاسیون های اپی ژنتیکی غیر طبیعی مثل سطح بالای متیلاسیون dna دارند. از آن جا که متیلاسیون در تکوین جنین در دوره ی قبل از لانه گزینی جایگاه مهم و حیاتی دارد، هایپر...
Recent studies have suggested an association between alcoholism and DNA methylation, a mechanism that can mediate long-lasting changes in gene transcription. Here, we examined the contribution of DNA methylation to the long-term behavioral and molecular changes induced by a history of alcohol dependence. In search of mechanisms underlying persistent rather than acute dependence-induced neuroada...
DNA methylation is an epigenetic mechanism for gene silencing engaged by DNA methyltransferase (Dnmt)-catalyzed methyl group transfer to cytosine residues in gene-regulatory regions. It is unknown whether aberrant DNA methylation can cause neurodegeneration. We tested the hypothesis that Dnmts can mediate neuronal cell death. Enforced expression of Dnmt3a induced degeneration of cultured NSC34 ...
THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND [SYSTEMATIC NAME: (2R)-3-(1H-indol-3-yl)-2-(4-nitro-1,3-dioxoisoindolin-2-yl)propanoic acid], C(19)H(13)N(3)O(6), an analogue of epigenetic modulator RG108, is constrained by strong hydrogen bonds between the indole N-H group and a carbonyl O atom of the phthalimide ring of a symmetry-related mol-ecule, and between the protonated O atom of the carboxy...
The dicyclo-hexyl-amine salt of RG108 (N-phthalyl-l-tryptophan) co-crystallizes with a water mol-ecule and a disordered mol-ecule of dimethyl-formamide (DMF), viz. dicyclo-hexyl-aminium (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoate dimethyl-formamide solvate monohydrate, C(12)H(24)N(+)·C(19)H(13)N(2)O(4) (-)·C(3)H(7)NO·H(2)O. The conformation of the deprotonated compound is const...
One of the major challenges of cocaine addiction is the high rate of relapse to drug use after periods of withdrawal. During the first few weeks of withdrawal, cue-induced cocaine craving intensifies, or "incubates," and persists over extended periods of time. Although several brain regions and molecular mechanisms were found to be involved in this process, the underlying epigenetic mechanisms ...
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