Abstract Background Growing evidence has implicated core-binding factor beta (Cbfb) as a contributor to osteoblast differentiation, which plays key role in fracture healing. Herein, we aimed assess whether Cbfb affects differentiation after fibula fracture. Methods Initially, established conditional knockout mouse model for subsequent studies. Immunohistochemical staining was conducted detect t...

a simple special protocol using semichon’s acetic carmine stain was applied for examination of muscles of some small mammals, naturally infected with sarcocystis spp. using this method, infected muscles fibers with sarcocystis could easily be differentiated from muscle tissues. this method can be applied for screening of infected muscles with sarcocystis cysts on large number of samples for epi...

ABH antigens are not expressed on the red blood cells of monkeys, making it difficult to accurately determine their blood type. In this study, we evaluated the feasibility, convenience, and stability of two non-invasive methods for ABO typing (a reverse gel system assay and a buccal mucosal cell immunofluorescent assay) in cynomolgus monkeys (n = 72). The renal tissue immunofluorescent assay wa...

objective: ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (mdma), is a potent neurotoxic drug. one of the mechanisms for its toxicity is the secondary release of glutamate. mouse embryonic stem cells (mescs) express only one glutamate receptor, the metabotropic glutamate receptor 5 (mglu5), which is involved in the maintenance and self-renewal of mescs. this study aims to investigate whethe...

BACKGROUND Recent studies have demonstrated telomerase expression in ophthalmologic sebaceous carcinoma and have suggested possible diagnostic utility in distinguishing these neoplasms from sebaceous adenomas. The aim of this study was to evaluate telomerase expression via human telomerase reverse transcriptase (hTERT) immunohistochemical staining in a spectrum of sebaceous lesions of the skin....

Platinum based combined chemotherapy have been proved to be the most effective drugs for ovarian cancer treatment, but it is difficult treat cisplatin resistant cancer. Carbobenzoxy-L-leucy-L-Leucyl-L-Leucinal (MG132) a reversible tripeptide aldehyde proteasome inhibitor, purpose of this study was observe effect MG132 on SKOV3 cell and OVCAR-3 expression autophagy apoptosis related factors. The...

background: lymphadenitis is a common form of extra-pulmonary tuberculosis. as in peripheral health centers, the facili­ties for histopathology and culture are lacking, material obtained by fine needle aspiration (fna) in suspected cases of tubercu­lar lymphadenitis (tbl) cid fast bacilli (afb) by ziehl neelson method as every designated micros­copy centre under revised national tuberculosis co...

background : cd117 is a thyrosin kinase receptor encoded by c-kit proto-oncogene. it is expressed during normal development in some tissues and also in a subset of neoplasia especially gastrointestinal stromal tumors   (gists). treatment with thyrosin kinase inhibitors (e.g., imatinib) is useful in cd117- positive gists. the goal of this study is to investigate the expression of cd117 in glial ...