Inhalation of toxins commonly found in air pollution contributes to the development and progression of asthma and environmental airway injury. In this study, we investigated the requirement of toll-like receptor 4 (TLR4) in mice for pulmonary responses to three environmental toxins: aerosolized lipopolysaccharide, particulate matter (residual oil fly ash), and ozone. The physiologic and biologi...

Although the Indian population is largely vegetarian, not much attention has been given to the cultivation of vegetables, as compared to other crops like cereals, pulses and oil seeds. Therefore, the present study was conducted on two leafy vegetables, spinach (Spanacia oleracea L.) and methi (Trigonella foenum graecum L.) commonly grown in Aligarh, as the two popular vegetables of Indian diet....

although the indian population is largely vegetarian, not much attention has been given to the cultivation of vegetables, as compared to other crops like cereals, pulses and oil seeds. therefore, the present study was conducted on two leafy vegetables, spinach (spanacia oleracea l.) and methi (trigonella foenum graecum l.) commonly grown in aligarh, as the two popular vegetables of indian diet....

Residential combustion has been identified as one of the main sources of particulate matter (PM); fine particles are important because of their adverse effects on human health and the environment. In this thesis, fine particle emissions originating from residential pellet combustion were characterized in different operational situations and using different raw materials as pellet fuel. Moreover...

We present self-modeling regression models for flexible nonparametric modeling of multiple outcomes measured longitudinally. Based on penalized regression splines, the models borrow strength across multiple outcomes by specifying a global time profile, thereby yielding a means of dimension reduction and estimates of trend more precise than those based on univariate regressions. The proposed mod...

Large-scale releases of environmental contaminants from industrial facilities can cause considerable damage to surrounding ecosystems and require remediation. The expense and/or undesirable environmental side effects of physical removal may constrain remediation efforts. In 2008, approximately 4.1 million m3 of fly ash were released into the Emory River at a coal-burning power plant in Kingston...

Many epidemiologic reports associate ambient levels of particulate matter (PM) with human mortality and morbidity, particularly in people with preexisting cardiopulmonary disease (e.g., chronic obstructive pulmonary disease, infection, asthma). Because much ambient PM is derived from combustion sources, we tested the hypothesis that the health effects of PM arise from anthropogenic PM that cont...